| Literature DB >> 4753235 |
Abstract
Normally the kidneys respond to an acid load by increased ammonia production. In six patients with adult-type diabetes this response was reduced by a mean 50% after a therapeutic dose of phenformin. The reduced ability to compensate for acid loads may be one factor leading to metabolic acidosis and lactoacidosis sometimes associated with phenformin therapy.Entities:
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Year: 1973 PMID： 4753235 PMCID： PMC1587345 DOI： 10.1136/bmj.4.5887.256
Source DB: PubMed Journal: Br Med J ISSN： 0007-1447