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Literature DB >> 4752038

Disturbance of cell-mediated immunity in patients with carcinoma of colon and rectum.

O N Manousos, J Economidou, C Pathouli, G Merikas.

Abstract

The cellular immune mechanisms of patients with adenocarcinoma of colon or rectum were evaluated by studying the lymphocyte response to PHA stimulation. Our results indicate that the serum of cancer patients causes a decreased blastic transformation and H(3) thymidine uptake of the lymphocytes of patients as well as of normal controls. A defect of the lymphocytes unrelated to serum factors was also present in some cancer patients. However, no relationship was found between the degree of transformation and the presence of metastases in the lymph nodes.

Entities: Chemical Disease Species

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Year: 1973 PMID： 4752038 PMCID： PMC1412773 DOI： 10.1136/gut.14.9.739

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

17 in total

1. Mitogenic effect of phytohaemagglutinin at different ages.

Authors: A V Pisciotta; D W Westring; C DePrey; B Walsh
Journal: Nature Date: 1967-07-08 Impact factor: 49.962

2. Cellular and humoral immunity to different types of human neoplasms.

Authors: I Hellström; K E Hellström; G E Pierce; J P Yang
Journal: Nature Date: 1968-12-28 Impact factor: 49.962

3. The presence of delayed hypersensitivity reactions in patients toward cellular extracts of their malignant tumors. 1. The role of tissue antigen, nonspecific reactions of nuclear material, and bacterial antigen as a cause for this phenomenon.

Authors: T H Stewart
Journal: Cancer Date: 1969-06 Impact factor: 6.860

Disturbance of cell-mediated immunity in patients with carcinoma of colon and rectum.

1. Mitogenic effect of phytohaemagglutinin at different ages.

2. Cellular and humoral immunity to different types of human neoplasms.

3. The presence of delayed hypersensitivity reactions in patients toward cellular extracts of their malignant tumors. 1. The role of tissue antigen, nonspecific reactions of nuclear material, and bacterial antigen as a cause for this phenomenon.

Review 4. The cellular basis of immunological responses. A synthesis of some current views.

5. Effect of plasma from patients with carcinoma on in vitro lymphocyte transformation.

6. Effect of serum from cancer patients on homologous lymphocyte cultures.

7. Delayed hypersensitivity in cancer patients: cutaneous and in vitro lymphocyte response to specific antigens.

8. Immunosuppressive effect of surgery.

9. Lymphocyte response to phytohemagglutinin in Hodgkin's disease, lymphatic leukemia and lymphosarcoma.

10. Immunological significance of the morphological changes in lymph nodes draining breast cancer.

1. Reversal of defective lymphoproliferation in postoperative patients with colon cancer.

2. [Carcinofetal antigens. III. Further carcinofetal antigens (author's transl)].