Literature DB >> 4750810

Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice.

P E Thomas, J J Hutton, B A Taylor.   

Abstract

Inbred strains of mice show differential skin inflammatory reactivity following the topical application of polycyclic hydrocarbons. Strains also differ in the extent to which hepatic aryl hydrocarbon hydroxylase activity is induced by these compounds. Differential inflammatory response and hydroxylase inducibility are genetically controlled by alleles at the In and Ahh loci, respectively. Genetic analyses and strain surveys indicate that the In and Ahh loci are identical, or very closely linked.

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Year:  1973        PMID： 4750810      PMCID： PMC1212981     

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  8 in total

1.  Host-gene control of C-type RNA tumor virus: inheritance of the group-specific antigen of murine leukemia virus.

Authors:  B A Taylor; H Meier; D D Myers
Journal:  Proc Natl Acad Sci U S A       Date:  1971-12       Impact factor: 11.205

2.  [Thin layer chromatographic separation and spectrophoto-fluometric identification of psychotropic drugs].

Authors:  S Lauffer; E Schmid; F Weist
Journal:  Arzneimittelforschung       Date:  1969-12

3.  Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo.

Authors:  J E Gielen; F M Goujon; D W Nebert
Journal:  J Biol Chem       Date:  1972-02-25       Impact factor: 5.157

4.  Aryl hydrocarbon hydroxylase, epoxide hydrase, and 7,12-dimethylbenz(a)anthracene-produced skin tumorigenesis in the mouse.

Authors:  D W Nebert; W F Benedict; J E Gielen; F Oesch; J W Daly
Journal:  Mol Pharmacol       Date:  1972-05       Impact factor: 4.436

5.  Epoxides of carcinogenic polycyclic hydrocarbons are frameshift mutagens.

Authors:  B N Ames; P Sims; P L Grover
Journal:  Science       Date:  1972-04-07       Impact factor: 47.728

6.  Dimethylbenzanthracene tumorigenesis and aryl hydrocarbon hydroxylase in mouse skin: inhibition by 7,8-benzoflavone.

Authors:  H V Gelboin; F Wiebel; L Diamond
Journal:  Science       Date:  1970-10-09       Impact factor: 47.728

7.  In vitro transformation of rodent cells by K-region derivatives of polycyclic hydrocarbons.

Authors:  P L Grover; P Sims; E Huberman; H Marquardt; T Kuroki; C Heidelberger
Journal:  Proc Natl Acad Sci U S A       Date:  1971-06       Impact factor: 11.205

8.  Enzymatic hydroxylation of benzopyrene and its relationship to cytotoxicity.

Authors:  H V Gelboin; E Huberman; L Sachs
Journal:  Proc Natl Acad Sci U S A       Date:  1969-12       Impact factor: 11.205
  8 in total
  8 in total

Review 1.  Metabolism of a prototype mycotoxin, aflatoxin B1, and its genetic regulation.

Authors:  H L Gurtoo; R Dahms; J B Vaught
Journal:  Mycopathologia       Date:  1978-12-18       Impact factor: 2.574

Review 2.  Mouse chromosome 12.

Authors:  P D'Eustachio
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

3.  Aryl hydrocarbon hydroxylase induction by benzo[a]anthracene: regulatory gene localized to the distal portion of mouse chromosome 17.

Authors:  C Legraverend; S O Kärenlampi; S W Bigelow; P A Lalley; C A Kozak; J E Womack; D W Nebert
Journal:  Genetics       Date:  1984-07       Impact factor: 4.562

4.  Lack of ecotropic virus involvement in induction of lymphomas in DBA/2J mice by 7,12-dimethylbenz(a)anthracene.

Authors:  J A Mercer; N A Jenkins; N G Copeland
Journal:  J Virol       Date:  1990-10       Impact factor: 5.103

5.  The genetic basis of susceptibility to leukemia induction in mice by 3-methylcholanthrene applied percutaneously.

Authors:  M L Duran-Reynals; F Lilly; A Bosch; K J Blank
Journal:  J Exp Med       Date:  1978-02-01       Impact factor: 14.307

6.  Genetic aspects of toxicity during development.

Authors:  D W Nebert; S S Thorgeirsson; G H Lambert
Journal:  Environ Health Perspect       Date:  1976-12       Impact factor: 9.031

Review 7.  Genetic differences in susceptibility to chemically induced myelotoxicity and leukemia.

Authors:  D W Nebert
Journal:  Environ Health Perspect       Date:  1981-06       Impact factor: 9.031

Review 8.  Effects of structure on binding to the 2,3,7,8-TCDD receptor protein and AHH induction--halogenated biphenyls.

Authors:  S Safe; S Bandiera; T Sawyer; B Zmudzka; G Mason; M Romkes; M A Denomme; J Sparling; A B Okey; T Fujita
Journal:  Environ Health Perspect       Date:  1985-09       Impact factor: 9.031
  8 in total

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