Literature DB >> 4749280

Aberration of porphyrin metabolism in iron-deficient anaemic rats.

D C Sharma.   

Abstract

Iron-deficient rats excreted greater amounts of 5-aminolaevulinate in urine but the output of porphobilinogen was decreased considerably. In addition, activity of the enzyme 5-aminolaevulinate dehydratase was diminished in bone marrow and liver. The results suggest that in iron deficiency a defect occurs in porphyrin synthesis at the level of porphobilinogen formation.

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Year:  1973        PMID: 4749280      PMCID: PMC1177881          DOI: 10.1042/bj1340821

Source DB:  PubMed          Journal:  Biochem J        ISSN: 0264-6021            Impact factor:   3.857


  16 in total

1.  A COMPARATIVE STUDY OF PORPHYRIN BIOSYNTHESIS IN DIFFERENT TISSUES.

Authors:  V M SARDESAI; J WALDMAN; J M ORTEN
Journal:  Blood       Date:  1964-08       Impact factor: 22.113

2.  In vitro pyrrole and porphyrin synthesis in lead poisoning and iron deficiency.

Authors:  H C LICHTMAN; F FELDMAN
Journal:  J Clin Invest       Date:  1963-06       Impact factor: 14.808

3.  Mitochondrial coproporphyrinogen oxidase and protoporphyrin formation.

Authors:  S SANO; S GRANICK
Journal:  J Biol Chem       Date:  1961-04       Impact factor: 5.157

4.  Erythrocyte delta-amino-laevulinic acid dehydrase in anaemia.

Authors:  G F RUBINO; G TESO; L RASETTI
Journal:  Acta Haematol       Date:  1960-12       Impact factor: 2.195

5.  The occurrence and determination of delta-amino-levulinic acid and porphobilinogen in urine.

Authors:  D MAUZERALL; S GRANICK
Journal:  J Biol Chem       Date:  1956-03       Impact factor: 5.157

6.  Urinary excretion of citrate, succinate and ketone bodies by iron-deficient rats.

Authors:  D C Sharma; P P Singh; M M Simlot
Journal:  Br J Nutr       Date:  1972-09       Impact factor: 3.718

7.  Erythrocyte protoporphyrin.

Authors:  E E Langer; R G Haining; R F Labbe; P Jacobs; E F Crosby; C A Finch
Journal:  Blood       Date:  1972-07       Impact factor: 22.113

8.  Erythrocyte delta-aminolaevulic acid dehydrase activity in anaemia.

Authors:  V Battistini; J J Morrow; D Ginsburg; G Thompson; M R Moore; A Goldberg
Journal:  Br J Haematol       Date:  1971-02       Impact factor: 6.998

9.  Magnetic particles in the liver: a probe for intracellular movement.

Authors:  P Gehr; J D Brain; S B Bloom; P A Valberg
Journal:  Nature       Date:  1983 Mar 24-30       Impact factor: 49.962

10.  Porphyrin biosynthesis in the erythrocytes of patients with sideropenic anaemias.

Authors:  O Gutniak; M Kopéc; J Nieczaj
Journal:  J Clin Pathol       Date:  1971-05       Impact factor: 3.411

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