Literature DB >> 4736831

Monoclonal production of both IgM and IgG1 antihapten antibody.

J L Press, N R Klinman.   

Abstract

The anti-DNP antibodies produced by primary and secondary splenic foci were analyzed for heavy chain class by a radioimmunoassay, using iodinated, purified goat antimouse micro-chain antibody and goat antimouse gamma1 chain antibody. The frequency of primary and secondary foci producing both IgM and IgG1 anti-DNP antibody (16% and 14%, respectively) was considerably higher than that which would be predicted by a random distribution. It would thus appear that IgM and IgG1 antibody can be made by the clonal progeny of a single precursor cell.

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Year:  1973        PMID： 4736831      PMCID： PMC2180547          DOI： 10.1084/jem.138.1.300

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  19 in total

1.  The stimulation of splenic foci in vitro.

Authors:  N R Klinman; G Aschinazi
Journal:  J Immunol       Date:  1971-05       Impact factor: 5.422

Review 2.  Somatic translocation of antibody genes.

Authors:  J A Gally; G M Edelman
Journal:  Nature       Date:  1970-07-25       Impact factor: 49.962

3.  The identity of light chains of monoclonal IgG and monoclonal IgM in one patient.

Authors:  A C Wang; I Y Wang; J N McCormick; H H Fudenberg
Journal:  Immunochemistry       Date:  1969-05

4.  Purification and analysis of "monofocal" antibody.

Authors:  N R Klinman
Journal:  J Immunol       Date:  1971-05       Impact factor: 5.422

5.  Sharing of individual antigenic determinants between a gamma G and a gamma M protein in the same myeloma serum.

Authors:  G M Penn; H G Kunkel; H M Grey
Journal:  Proc Soc Exp Biol Med       Date:  1970-12

6.  A variable region subclass of heavy chains common to immunoglobulins G, A, and M and characterized by an unblocked amino-terminal residue.

Authors:  A C Wang; J R Pink; H H Fudenberg; J Ohms
Journal:  Proc Natl Acad Sci U S A       Date:  1970-07       Impact factor: 11.205

7.  Evidence for control of synthesis of the varible regions of the heavy chains of immunoglobulins G and M by the same gene.

Authors:  A C Wang; K S Wilson; J E Hopper; H H Fudenberg; A Nisonoff
Journal:  Proc Natl Acad Sci U S A       Date:  1970-06       Impact factor: 11.205

8.  Incidence of cells simultaneously secreting IgM and IgG antibody to sheep erythrocytes.

Authors:  G J Nossal; N L Warner; H Lewis
Journal:  Cell Immunol       Date:  1971-02       Impact factor: 4.868

9.  Immunoglobulin spots on the surface of rabbit lymphocytes.

Authors:  B Pernis; L Forni; L Amante
Journal:  J Exp Med       Date:  1970-11       Impact factor: 14.307

10.  SINGLE CELL STUDIES ON 19S ANTIBODY PRODUCTION.

Authors:  G J NOSSAL; A SZENBERG; G L ADA; C M AUSTIN
Journal:  J Exp Med       Date:  1964-03-01       Impact factor: 14.307
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  16 in total

Review 1.  A transcriptional serenAID: the role of noncoding RNAs in class switch recombination.

Authors:  William T Yewdell; Jayanta Chaudhuri
Journal:  Int Immunol       Date:  2017-04-01       Impact factor: 4.823

2.  Optimal strategies in immunology III. The IgM-IgG switch.

Authors:  A S Perelson; B Goldstein; S Rocklin
Journal:  J Math Biol       Date:  1980-11       Impact factor: 2.259

3.  Clones producing antibodies of more than one class.

Authors:  H Kolb; M J Bosma
Journal:  Immunology       Date:  1977-10       Impact factor: 7.397

4.  The class of surface immunoglobulin on cells carrying IgG memory in rat thoracic duct lymph: the size of the subpopulation mediating IgG memory.

Authors:  D W Mason
Journal:  J Exp Med       Date:  1976-05-01       Impact factor: 14.307

5.  Restriction of gene expression in B lymphocytes and their progeny. II. Commitment to immunoglobulin heavy chain isotype.

Authors:  P P Jones; S W Craig; J J Cebra; L A Herzenberg
Journal:  J Exp Med       Date:  1974-08-01       Impact factor: 14.307

6.  The monoclonal anti-phosphorylcholine antibody response in several murine strains: genetic implications of a diverse repertoire.

Authors:  P J Gearhart; N H Sigal; N R Klinman
Journal:  J Exp Med       Date:  1977-04-01       Impact factor: 14.307

7.  Monoclonal rat anti-major histocompatibility complex antibodies display specificity for rat, mouse, and human target cells.

Authors:  D E Smilek; H C Boyd; D B Wilson; C M Zmijewski; F W Fitch; T J McKearn
Journal:  J Exp Med       Date:  1980-05-01       Impact factor: 14.307

8.  Heterogeneity of the BALB/c antiphosphorylcholine antibody response at the precursor cell level.

Authors:  P J Gearhart; N H Sigal; N R Klinman
Journal:  J Exp Med       Date:  1975-01-01       Impact factor: 14.307

9.  Clonal analysis of primary B cells responsive to the pathogenic bacterium Salmonella typhimurium.

Authors:  L W Duran; E S Metcalf
Journal:  J Exp Med       Date:  1987-02-01       Impact factor: 14.307

10.  T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells.

Authors:  P C Isakson; E Puré; E S Vitetta; P H Krammer
Journal:  J Exp Med       Date:  1982-03-01       Impact factor: 14.307
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