Literature DB >> 4734649

Reovirus: effect of noninfective viral components on cellular deoxyribonucleic acid synthesis.

R Hand, I Tamm.   

Abstract

We determined the effects of noninfective reovirus components on cellular deoxyribonucleic acid (DNA) synthesis. Reovirus inactivated by ultraviolet light inhibited cellular DNA synthesis, whereas reovirus cores and empty capsids did not. Both cores and empty capsids were adsorbed to cells. Adenine-rich ribonucleic acid (RNA) from reovirus, adsorbed to cells in the presence of diethyl-aminoethyl-dextran, produced a partial inhibition of DNA synthesis. RNA was synthesized in the presence of actinomycin D after infection with ultraviolet light-irradiated reovirus, and this RNA synthesis was not due to multiplicity reactivation of virus infectivity. These data suggest that viral structural proteins do not inhibit DNA synthesis and that the inhibition produced by ultraviolet-irradiated virus may be mediated in part or in toto by a newly synthesized viral product.

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Year:  1973        PMID： 4734649      PMCID： PMC355086          DOI： 10.1128/JVI.11.2.223-231.1973

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  29 in total

1.  Hybridization and sedimentation studies on "early" and "late" vaccinia messenger RNA.

Authors:  K I Oda; W K Joklik
Journal:  J Mol Biol       Date:  1967-08-14       Impact factor: 5.469

2.  Cellular DNA and protein synthesis in reovirus-infected L cells.

Authors:  W D Ensminger; I Tamm
Journal:  Virology       Date:  1969-10       Impact factor: 3.616

3.  Polypeptide components of virions, top component and cores of reovirus type 3.

Authors:  R E Smith; H J Zweerink; W K Joklik
Journal:  Virology       Date:  1969-12       Impact factor: 3.616

4.  Structural proteins of reoviruses.

Authors:  P C Loh; A J Shatkin
Journal:  J Virol       Date:  1968-11       Impact factor: 5.103

5.  Growth characteristics of reovirus type 2: ultraviolet light inactivated virion preparations and cell death.

Authors:  P C Loh; H K Oie
Journal:  Arch Gesamte Virusforsch       Date:  1969

6.  Viral RNA synthesis in chicken cells infected with ultraviolet irradiated Newcastle Disease Virus.

Authors:  J Huppert; J Hillova; L Gresland
Journal:  Nature       Date:  1969-09-06       Impact factor: 49.962

7.  Single-stranded, adenine-rich RNA from purified reoviruses.

Authors:  A J Shatkin; J D Sipe
Journal:  Proc Natl Acad Sci U S A       Date:  1968-01       Impact factor: 11.205

8.  Studies on reovirus RNA. I. Characterization of reovirus genome RNA.

Authors:  A R Bellamy; L Shapiro; J T August; W K Joklik
Journal:  J Mol Biol       Date:  1967-10-14       Impact factor: 5.469

9.  Multiplicity reactivation of reovirus particles after exposure to ultraviolet light.

Authors:  M E McClain; R S Spendlove
Journal:  J Bacteriol       Date:  1966-11       Impact factor: 3.490

10.  Synthesis of reovirus ribonucleic acid in L cells.

Authors:  H Kudo; A F Graham
Journal:  J Bacteriol       Date:  1965-10       Impact factor: 3.490
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  9 in total

1.  Reovirus variants with mutations in genome segments S1 and L2 exhibit enhanced virion infectivity and superior oncolysis.

Authors:  Maya Shmulevitz; Shashi A Gujar; Dae-Gyun Ahn; Adil Mohamed; Patrick W K Lee
Journal:  J Virol       Date:  2012-04-24       Impact factor: 5.103

2.  Development of biologically active peptides based on antibody structure.

Authors:  W V Williams; D A Moss; T Kieber-Emmons; J A Cohen; J N Myers; D B Weiner; M I Greene
Journal:  Proc Natl Acad Sci U S A       Date:  1989-07       Impact factor: 11.205

3.  Inhibition of the initiation of cellular DNA synthesis after reovirus infection.

Authors:  D C Cox; J E Shaw
Journal:  J Virol       Date:  1974-03       Impact factor: 5.103

4.  Molecular determinants of proteolytic disassembly of the reovirus outer capsid.

Authors:  Joshua D Doyle; Pranav Danthi; Emily A Kendall; Laura S Ooms; J Denise Wetzel; Terence S Dermody
Journal:  J Biol Chem       Date:  2012-01-17       Impact factor: 5.157

5.  Reovirus inhibition of cellular DNA synthesis: role of the S1 gene.

Authors:  A H Sharpe; B N Fields
Journal:  J Virol       Date:  1981-04       Impact factor: 5.103

6.  The preferential cytotoxicity of reovirus for certain transformed cell lines.

Authors:  G Hashiro; P C Loh; J T Yau
Journal:  Arch Virol       Date:  1977       Impact factor: 2.574

7.  The multi-functional reovirus σ3 protein is a virulence factor that suppresses stress granule formation and is associated with myocardial injury.

Authors:  Yingying Guo; Meleana M Hinchman; Mercedes Lewandrowski; Shaun T Cross; Danica M Sutherland; Olivia L Welsh; Terence S Dermody; John S L Parker
Journal:  PLoS Pathog       Date:  2021-07-08       Impact factor: 6.823

8.  Cellular integrity is required for inhibition of initiation of cellular DNA synthesis by reovirus type 3.

Authors:  M R Roner; D C Cox
Journal:  J Virol       Date:  1985-02       Impact factor: 5.103

9.  Inhibition of cellular DNA synthesis by reovirus occurs through a receptor-linked signaling pathway that is mimicked by antiidiotypic, antireceptor antibody.

Authors:  G N Gaulton; M I Greene
Journal:  J Exp Med       Date:  1989-01-01       Impact factor: 14.307
  9 in total

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