Literature DB >> 4734201

Inhibition of phenylethanolamine N-methyltransferase by benzylamines. 1. Structure-activity relationships.

R W Fuller, B B Molloy, W A Day, B W Roush, M M Marsh.   

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Year:  1973        PMID： 4734201     DOI： 10.1021/jm00260a003

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  2 in total

1.  Application of the Goldilocks effect to the design of potent and selective inhibitors of phenylethanolamine N-methyltransferase: balancing pKa and steric effects in the optimization of 3-methyl-1,2,3,4-tetrahydroisoquinoline inhibitors by beta-fluorination.

Authors:  Gary L Grunewald; Mitchell R Seim; Jian Lu; Mariam Makboul; Kevin R Criscione
Journal:  J Med Chem       Date:  2006-05-18       Impact factor: 7.446

2.  Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase.

Authors:  Gary L Grunewald; Mitchell R Seim; Seema R Bhat; Marc E Wilson; Kevin R Criscione
Journal:  Bioorg Med Chem       Date:  2007-10-11       Impact factor: 3.641
  2 in total

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