Literature DB >> 4730826

Tolerance to the hypothermic effects of 9-tetrahydrocannabinol as a function of age in the chicken.

E L Abel, D E McMillan, L S Harris.   

Abstract

1. (-)-Delta(9)-Tetrahydrocannabinol was administered to chicks (Gallus domesticus) of various ages and body temperature and tolerance to the hypothermic effects of the drug were examined as a function of age.2. The hypothermic effects were found to be greater in neonatal than older animals and likewise tolerance took longer to develop in younger chicks.3. The rate of tolerance development, however, could be increased in the neonate by preadministration of a high dose of the drug.

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Year:  1973        PMID： 4730826      PMCID： PMC1776369          DOI： 10.1111/j.1476-5381.1973.tb08176.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  6 in total

1.  Pharmacologic basis for the increased sensitivity of the newborn rat to morphine.

Authors:  H J KUPFERBERG; E L WAY
Journal:  J Pharmacol Exp Ther       Date:  1963-07       Impact factor: 4.030

2.  Chlorpromazine hyperthermia in young albino mice.

Authors:  W J BAGDON; D E MANN
Journal:  J Pharm Sci       Date:  1962-08       Impact factor: 3.534

Review 3.  Developmental pharmacology.

Authors:  F Sereni; N Principi
Journal:  Annu Rev Pharmacol       Date:  1968       Impact factor: 13.820

4.  Homeothermic development of the young chick.

Authors:  D R Wekstein; J F Zolman
Journal:  Proc Soc Exp Biol Med       Date:  1967-05

5.  Acute toxicity and lethal brain concentration of pentobarbital in young and adult albino rats.

Authors:  J R Bianchine; F C Ferguson
Journal:  Proc Soc Exp Biol Med       Date:  1967-04

6.  Effects of catecholamines infused into the brain of young chickens.

Authors:  E Marley; J D Stephenson
Journal:  Br J Pharmacol       Date:  1970-12       Impact factor: 8.739
  6 in total

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