Literature DB >> 47308

Genetic control of sensitization to structurally unrelated antigens and its relationship to histocompatibility antigens in guinea-pigs.

A F Greczy, A L de Weck.   

Abstract

Five strains of guinea-pigs homozygous for GPL-A and 2/13 histocompatibility antigens were sequentially immunized with seven structurally unrelated antigens (TGAL, BPO-BGG, ASAN, BPO-PLL, phenetidine, horseradish peroxidase and DNP-dodecapeptide). Considerable differences in the immune response were observed, as measured by delayed skin reactivity and antigen-induced lymphocyte stimulation in vitro. The data presented show that when the progeny of various back-cross matings are analysed for their responder status, the responses to the antigens (TGAL, BPO-BGG, phenetidine and ASAN) are in most cases linked to the genes controlling the respective histocompatibility antigens. However, it appears that the responses to the various antigens in our system may be under polygenic control.

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Year:  1975        PMID： 47308      PMCID： PMC1445802     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  16 in total

1.  Histocompatibility antigens and genetic control of the immune response in guinea pigs. I. Specific inhibition of antigen-induced lymphocyte stimulation by alloantisera.

Authors:  A F Geczy; A L De Weck
Journal:  Eur J Immunol       Date:  1974-07       Impact factor: 5.532

2.  Immunogenicity of fully defined lysine LAG dodecapeptides in guinea-pigs: with a note on an antigenic cooperation effect in the delayed immune response.

Authors:  C H Schneider; A L de Weck; E Schenkel; W Wirz; S Lazary
Journal:  Immunology       Date:  1972-12       Impact factor: 7.397

3.  [Antigenicity of hapten-polysaccharide conjugates].

Authors:  C H Schneider; J Michl; A L de Weck
Journal:  Eur J Immunol       Date:  1971-04       Impact factor: 5.532

4.  Immunological effects of aspirin anhydride, a contaminant of commercial acetylsalicylic acid preparations.

Authors:  A L De Weck
Journal:  Int Arch Allergy Appl Immunol       Date:  1971

5.  [Sensitization to phenacetin: immunological aspects].

Authors:  R Rüegger; H Spengler; A L de Weck; U C Dubach
Journal:  Dtsch Med Wochenschr       Date:  1973-04-13       Impact factor: 0.628

6.  Immune and non-immune responses to monovalent low molecular weight penicilloyl-polylysines and penicilloyl-bacitracin in rabbits and guinea-pigs.

Authors:  A L De Weck; C H Schneider
Journal:  Immunology       Date:  1968-04       Impact factor: 7.397

7.  Studies on the quantitation of lymphocyte response in vitro.

Authors:  S F Sorensen; V Andersen; J Giese
Journal:  Acta Pathol Microbiol Scand       Date:  1969

8.  Genetic and cellular factors in the immune response. II. Evidence for the polygenic control of the antibody response from further breeding studies and from pedigree analyses.

Authors:  T J Gill; H W Kunz
Journal:  J Immunol       Date:  1971-04       Impact factor: 5.422

9.  Linkage between the poly-L-lysine gene and the locus controlling the major histocompatibility antigens in strain 2 guinea pigs.

Authors:  L Ellman; I Green; W J Martin; B Benacerraf
Journal:  Proc Natl Acad Sci U S A       Date:  1970-06       Impact factor: 11.205

10.  STUDIES ON ARTIFICIAL ANTIGENS. III. THE GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAPTEN-POLY-L-LYSINE CONJUGATES IN GUINEA PIGS.

Authors:  B B LEVINE; A OJEDA; B BENACERRAF
Journal:  J Exp Med       Date:  1963-12-01       Impact factor: 14.307
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  3 in total

1.  Allergic contact dermatitis to nickel is associated with a Taq I HLA-DQA allelic restriction fragment.

Authors:  O Olerup; L Emtestam
Journal:  Immunogenetics       Date:  1988       Impact factor: 2.846

2.  Direct skin test in highly sensitized guinea pigs for rapid and sensitive determination of staphylococcal enterotoxin B.

Authors:  P H Scheuber; H Mossmann; G Beck; D K Hammer
Journal:  Appl Environ Microbiol       Date:  1983-12       Impact factor: 4.792

3.  HLA-antigens in patients with allergic contact sensitivity to nickel.

Authors:  L R Braathen; O Haavelsrud; E Thorsby
Journal:  Arch Dermatol Res       Date:  1983       Impact factor: 3.017
  3 in total

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