| Literature DB >> 4730057 |
Abstract
In patients with vitamin B(12) deficiency, phytohemagglutinin-stimulated cultured lymphocytes had little or no thymidylate synthetase activity. Ample activity was found in such lymphocytes from normal individuals and patients with folic acid deficiency or pernicious anemia in remission. It therefore appears that the megaloblastosis that is associated with vitamin B(12) deficiency is related to low thymidylate synthetase activity.Entities:
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Year: 1973 PMID： 4730057 DOI： 10.1126/science.182.4107.78
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728