Literature DB >> 472759

Receptor-mediated internalization of fluorescent chemotactic peptide by human neutrophils.

J E Niedel, I Kahane, P Cuatrecasas.   

Abstract

Tetramethylrhodamine labeled N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys is a potent chemoattractant for human neutrophils. Binding of this peptide to living neutrophils was observed by means of video intensification microscopy. At 37 degrees C, diffuse membrane fluorescence was seen initially, followed by rapid aggregation and internalization of the fluorescent peptide. These processes are dependent on specific binding to the formal peptide chemotactic receptor.

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Year:  1979        PMID： 472759     DOI： 10.1126/science.472759

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  40 in total

1.  Conjugates bearing multiple formyl-methionyl peptides display enhanced binding to but not activation of phagocytic cells.

Authors:  Shahriar Pooyan; Bo Qiu; Marion M Chan; Dunne Fong; Patrick J Sinko; Michael J Leibowitz; Stanley Stein
Journal:  Bioconjug Chem       Date:  2002 Mar-Apr       Impact factor: 4.774

2.  Structural determinants for the interaction of formyl peptide receptor 2 with peptide ligands.

Authors:  Hui-Qiong He; Erica L Troksa; Gianluigi Caltabiano; Leonardo Pardo; Richard D Ye
Journal:  J Biol Chem       Date:  2013-11-27       Impact factor: 5.157

3.  Desensitization of calcium mobilization and cell function in human neutrophils.

Authors:  G H Lee; J S Kaptein; S J Scott; H Niedzin; C I Kalunta; P M Lad
Journal:  Biochem J       Date:  1989-08-15       Impact factor: 3.857

4.  Impermeant stilbene disulfonic acids block chemotactic peptide receptor function on human granulocytes.

Authors:  K M Skubitz; G M Vercellotti; C S Greenberg; J W Eaton
Journal:  Inflammation       Date:  1989-02       Impact factor: 4.092

Review 5.  Activation of the neutrophil respiratory burst by chemoattractants: regulation of the N-formyl peptide receptor in the plasma membrane.

Authors:  A J Jesaitis; R A Allen
Journal:  J Bioenerg Biomembr       Date:  1988-12       Impact factor: 2.945

6.  Corticosteroids block binding of chemotactic peptide to its receptor on granulocytes and cause disaggregation of granulocyte aggregates in vitro.

Authors:  K M Skubitz; P R Craddock; D E Hammerschmidt; J T August
Journal:  J Clin Invest       Date:  1981-07       Impact factor: 14.808

Review 7.  International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family.

Authors:  Richard D Ye; François Boulay; Ji Ming Wang; Claes Dahlgren; Craig Gerard; Marc Parmentier; Charles N Serhan; Philip M Murphy
Journal:  Pharmacol Rev       Date:  2009-06-04       Impact factor: 25.468

8.  Receptor-mediated internalization of fluorescent gonadotropin-releasing hormone by pituitary gonadotropes.

Authors:  E Hazum; P Cuatrecasas; J Marian; P M Conn
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

9.  Membrane activity and topography of F-Met-Leu-Phe-Treated polymorphonuclear leukocytes. Acute and sustained responses to chemotactic peptide.

Authors:  B H Davis; R J Walter; C B Pearson; E L Becker; J M Oliver
Journal:  Am J Pathol       Date:  1982-08       Impact factor: 4.307

10.  Plasma-membrane location of phosphatidylinositol hydrolysis in rabbit neutrophils stimulated with formylmethionyl-leucylphenylalanine.

Authors:  J P Bennett; S Cockcroft; A H Caswell; B D Gomperts
Journal:  Biochem J       Date:  1982-12-15       Impact factor: 3.857
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