Literature DB >> 472733

Iodine-125--labeled estradiol: a gamma-emitting analog of estradiol that binds to the estrogen receptor.

R B Hochberg.   

Abstract

17 beta-[16 alpha-125I]Iodoestradiol has been synthesized by exchange of 16 beta-bromoestradiol with Na125I. The iodinated product is readily separated from the bromo reactant by column chromatography. It concentrates in the rat uterus in vivo and binds avidly and specifically to the uterine estrogen receptor in vitro.

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Year:  1979        PMID： 472733     DOI： 10.1126/science.472733

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  10 in total

1.  Targeting the estrogen receptor with metal-carbonyl derivatives of estradiol.

Authors:  Robert N Hanson; Rein Kirss; Emmett McCaskill; Edward Hua; Pakamas Tongcharoensirikul; Sandra L Olmsted; David Labaree; Richard B Hochberg
Journal:  Bioorg Med Chem Lett       Date:  2012-01-08       Impact factor: 2.823

Review 2.  Targeted functional imaging in breast cancer.

Authors:  Rakesh Kumar
Journal:  Eur J Nucl Med Mol Imaging       Date:  2007-03       Impact factor: 9.236

3.  Interaction of 16 alpha-[125I]iodo-estradiol with estrogen receptor and other steroid-binding proteins.

Authors:  R B Hochberg; W Rosner
Journal:  Proc Natl Acad Sci U S A       Date:  1980-01       Impact factor: 11.205

4.  Kinetic changes of liver regeneration and hepatocellular carcinoma cells after partial hepatectomy in rats.

Authors:  T Namieno; N Takeichi; Y Hata; J Uchino; H Kobayashi
Journal:  Gastroenterol Jpn       Date:  1991-02

5.  Radioiodinated Ethinylestradiol Derivatives for Estrogen Receptor Targeting Breast Cancer Imaging.

Authors:  Huanhuan Liu; Xiaoru Lin; Duo Xu; Jingchao Li; Jianyang Fang; Jindian Li; Lingxin Meng; Xinying Zeng; Yesen Li; Jinxiong Huang; Zhide Guo; Xianzhong Zhang
Journal:  ACS Med Chem Lett       Date:  2022-01-27       Impact factor: 4.345

6.  Rapid and sensitive detection of oestrogen receptors in cells and tissue sections by autoradiography with 125I-oestradiol.

Authors:  E M Berns; F F Rommerts; E Mulder
Journal:  Histochem J       Date:  1985-11

7.  Dose-dependent change in tissue uptake of 17 beta-(16 alpha-[125I]iodo)-estradiol in female rats: application to external imaging of mammary carcinoma.

Authors:  S Noguchi; H Koyama; S Nakano
Journal:  Eur J Nucl Med       Date:  1984

8.  The stereoisomers of 17alpha-[123I]iodovinyloestradiol and its 11beta-methoxy derivative evaluated for their oestrogen receptor binding in human MCF-7 cells and rat uterus, and their distribution in immature rats.

Authors:  L J Rijks; G J Boer; E Endert; K de Bruin; J C van den Bos; P A van Doremalen; W G Schoonen; A G Janssen; E A van Royen
Journal:  Eur J Nucl Med       Date:  1996-03

9.  The uptake of radioiodinated 5 alpha-dihydrotestosterone by the prostate of intact and castrated rats.

Authors:  M Tarle; R Padovan; S Spaventi
Journal:  Eur J Nucl Med       Date:  1981-02

10.  26-[125I]iodoponasterone A is a potent ecdysone and a sensitive radioligand for ecdysone receptors.

Authors:  P Cherbas; L Cherbas; S S Lee; K Nakanishi
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205
  10 in total

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