Literature DB >> 4726444

N-nitrosation by nitrite ion in neutral and basic medium.

L K Keefer, P P Roller.   

Abstract

Formaldehyde catalyzed the conversion of various secondary amines to nitrosamines in the pH range 6.4 to 11.0. Chloral was also an effective catalyst. The reaction proceeds easily enough to have potential synthetic applications; the proposed mechanism could explain some reported anomalies regarding the synthesis of carcinogenic N-nitroso compounds in vivo and in vitro.

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Year:  1973        PMID： 4726444     DOI： 10.1126/science.181.4106.1245

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  6 in total

1.  2'-Hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: formation of a lung carcinogen precursor.

Authors:  S S Hecht; J B Hochalter; P W Villalta; S E Murphy
Journal:  Proc Natl Acad Sci U S A       Date:  2000-11-07       Impact factor: 11.205

Review 2.  The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment.

Authors:  Ivonne M C M Rietjens; Arand Michael; Hermann M Bolt; Bourdoux Siméon; Hartwig Andrea; Hinrichsen Nils; Kalisch Christine; Mally Angela; Pellegrino Gloria; Ribera Daniel; Thatcher Natalie; Eisenbrand Gerhard
Journal:  Arch Toxicol       Date:  2022-03-06       Impact factor: 6.168

3.  Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds-a hypothesis.

Authors:  Gerhard Eisenbrand; Matthias Baum; Alexander T Cartus; Patrick Diel; Karl-Heinz Engel; Barbara Engeli; Bernd Epe; Tilman Grune; Sabine Guth; Dirk Haller; Volker Heinz; Michael Hellwig; Jan G Hengstler; Thomas Henle; Hans-Ulrich Humpf; Henry Jäger; Hans-Georg Joost; Sabine Kulling; Dirk W Lachenmeier; Alfonso Lampen; Marcel Leist; Angela Mally; Doris Marko; Ute Nöthlings; Elke Röhrdanz; Angelika Roth; Joachim Spranger; Richard Stadler; Stefan Vieths; Wim Wätjen; Pablo Steinberg
Journal:  Arch Toxicol       Date:  2022-05-04       Impact factor: 6.168

4.  Dimethylnitrosamine--formation in fish meal and toxic effects in pigs.

Authors:  N Koppang
Journal:  Am J Pathol       Date:  1974-01       Impact factor: 4.307

5.  Rapid formation of carcinogenic N-nitrosamines in aqueous alkaline solutions.

Authors:  B C Challis; S A Kyrtopoulos
Journal:  Br J Cancer       Date:  1977-05       Impact factor: 7.640

6.  Salmonella typhimurium TA100 and TA1535 and E. coli WP2 uvrA are highly sensitive to detect the mutagenicity of short Alkyl-N-Nitrosamines in the Bacterial Reverse Mutation Test.

Authors:  Frank Bringezu; Stephanie Simon
Journal:  Toxicol Rep       Date:  2022-02-08
  6 in total

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