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Literature DB >> 4725697

Pyrogenicity and immunogenicity of lipid A complexed with bovine serum albumin or human serum albumin.

E T Rietschel, Y B Kim, D W Watson, C Galanos, O Lüderitz, O Westphal.

Abstract

The lipid A component of bacterial lipopolysaccharides (endotoxins), when complexed to bovine serum albumin (BSA) or human serum albumin (HSA), was shown to be a potent pyrogen. Furthermore, rabbits could be protected against endotoxin fever by immunization with both lipid A.BSA and lipid A.HSA complexes. The results presented in this paper show that lipid A is responsible for the pyrogenic activity of endotoxins and their ability to induce pyrogenic immunity.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1973 PMID： 4725697 PMCID： PMC422829 DOI： 10.1128/iai.8.2.173-177.1973

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

15 in total

1. Interaction of lipopolysaccharides and lipid A with complement.

Authors: C Galanos; E T Rietschel; O Lüderitz; O Westphal
Journal: Eur J Biochem Date: 1971-03-01

2. Mechanisms of endotoxin tolerance. VI. Transfer of the "anamnestic" tolerant response with primed spleen cells.

Authors: S E Greisman; E J Young
Journal: J Immunol Date: 1969-12 Impact factor: 5.422

3. Mechanisms of endotoxin tolerance. V. Specificity of the early and late phases of pyrogenic tolerance.

Authors: S E Greisman; E J Young; F A Carozza
Journal: J Immunol Date: 1969-12 Impact factor: 5.422

Review 4. Molecular aspects of endotoxic reactions.

Authors: A Nowotny
Journal: Bacteriol Rev Date: 1969-03

5. [A new laboratory fermentor for the cultivation of microorganisms by means of turbidostatical, chemostatical and "batch" methods. I. Technical description of the fermentor].

Authors: S Schlecht; K Ring; J Kutscher; W Eschweiler
Journal: Zentralbl Bakteriol Orig Date: 1968-03

6. Biological activities of chemically modified endotoxins.

Authors: E T Rietschel; C Galanos; A Tanaka; E Ruschmann; O Lüderitz; O Westphal
Journal: Eur J Biochem Date: 1971-09-24

7. A new method for the extraction of R lipopolysaccharides.

Authors: C Galanos; O Lüderitz; O Westphal
Journal: Eur J Biochem Date: 1969-06

8. Structural relationship of Salmonella O and R antigens.

Authors: O Lüderitz; C Galanos; H J Risse; E Ruschmann; S Schlecht; G Schmidt; H Schulte-Holthausen; R Wheat; O Westphal; J Schlosshardt
Journal: Ann N Y Acad Sci Date: 1966-06-30 Impact factor: 5.691

9. Biologically active endotoxins from Salmonella mutants deficient in O- and R-polysaccharides and heptose.

Authors: Y B Kim; D W Watson
Journal: J Bacteriol Date: 1967-11 Impact factor: 3.490

10. MODIFICATION OF HOST RESPONSES TO BACTERIAL ENDOTOXINS. II. PASSIVE TRANSFER OF IMMUNIY TO BACTERIAL ENDOTOXIN WITH FRACTIONS CONTAINING 19S ANTIBODIES.

Authors: Y B KIM; D W WATSON
Journal: J Exp Med Date: 1965-05-01 Impact factor: 14.307

25 in total

Pyrogenicity and immunogenicity of lipid A complexed with bovine serum albumin or human serum albumin.

1. Interaction of lipopolysaccharides and lipid A with complement.

2. Mechanisms of endotoxin tolerance. VI. Transfer of the "anamnestic" tolerant response with primed spleen cells.

3. Mechanisms of endotoxin tolerance. V. Specificity of the early and late phases of pyrogenic tolerance.

Review 4. Molecular aspects of endotoxic reactions.

5. [A new laboratory fermentor for the cultivation of microorganisms by means of turbidostatical, chemostatical and "batch" methods. I. Technical description of the fermentor].

6. Biological activities of chemically modified endotoxins.

7. A new method for the extraction of R lipopolysaccharides.

8. Structural relationship of Salmonella O and R antigens.

9. Biologically active endotoxins from Salmonella mutants deficient in O- and R-polysaccharides and heptose.

10. MODIFICATION OF HOST RESPONSES TO BACTERIAL ENDOTOXINS. II. PASSIVE TRANSFER OF IMMUNIY TO BACTERIAL ENDOTOXIN WITH FRACTIONS CONTAINING 19S ANTIBODIES.

1. Mechanisms of endotoxin tolerance. The role of the spleen.

2. The last round against bacterial infections?

3. Interferon production in mice by components of Salmonella minnesota R595 lipid A.

Review 4. Immunotherapeutic advances in the treatment of gram-negative bacterial sepsis.

5. Heterogeneity of lipid A: comparison of lipid A types from different gram-negative bacteria.

6. On the pyrogenic action of intravenous lipid A in rabbits.

7. Lipid A and anti-lipid A.

Review 8. The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.

9. Lipid A antiserum-mediated protection against lipopolysaccharide- and lipid A-induced fever and skin necrosis.

10. Characterization of the lipopolysaccharide from Vibrio cholerae 395 (Ogawa).