Literature DB >> 4724930

Differences in collagen metabolism between normal and osteoarthritic human articular cartilage.

M Nimni, K Deshmukh.   

Abstract

Normal human articular cartilage synthesizes only one type of a chain, which exhibits the chromatographic behavior of the alpha(l)(II) chains described for chick and bovine cartilage. Osteoarthritic cartilage, on the other hand, synthesizes in addition a collagen containing alpha(2) chains and beta components. The different structural features of the two types of collagen may account for some of the functional defects of osteoarthritic cartilage.

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Year:  1973        PMID： 4724930     DOI： 10.1126/science.181.4101.751

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  39 in total

1.  Biochemical characteristics and biological significance of the genetically-distinct collagens.

Authors:  E J Miller
Journal:  Mol Cell Biochem       Date:  1976-12-10       Impact factor: 3.396

2.  Changes in type of collagen synthesized as clones of chick chondrocytes grow and eventually lose division capacity.

Authors:  R Mayne; M S Vail; P M Mayne; E J Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1976-05       Impact factor: 11.205

3.  Phenotypic modulation of chondrocytes as a potential therapeutic target in osteoarthritis: a hypothesis.

Authors:  T Aigner; J Dudhia
Journal:  Ann Rheum Dis       Date:  1997-05       Impact factor: 19.103

4.  Isolation and partial characterization of the entire human pro alpha 1(II) collagen gene.

Authors:  F O Sangiorgi; V Benson-Chanda; W J de Wet; M E Sobel; P Tsipouras; F Ramirez
Journal:  Nucleic Acids Res       Date:  1985-04-11       Impact factor: 16.971

5.  Biosynthesis of collagen and other matrix proteins by articular cartilage in experimental osteoarthrosis.

Authors:  D R Eyre; C A McDevitt; M E Billingham; H Muir
Journal:  Biochem J       Date:  1980-06-15       Impact factor: 3.857

6.  Independent expression of fibril-forming collagens I, II, and III in chondrocytes of human osteoarthritic cartilage.

Authors:  T Aigner; W Bertling; H Stöss; G Weseloh; K von der Mark
Journal:  J Clin Invest       Date:  1993-03       Impact factor: 14.808

7.  Change in collagen synthesis of human chondrocyte culture. I. Development of a human model, demonstration of collagen type conversion by immunofluorescence.

Authors:  G J Zlabinger; J E Menzel; C Steffen
Journal:  Rheumatol Int       Date:  1986       Impact factor: 2.631

8.  Chondrocytes synthesize type I collagen and accumulate the protein in the matrix during development of rat tibial articular cartilage.

Authors:  Y Sasano; M Furusawa; H Ohtani; I Mizoguchi; I Takahashi; M Kagayama
Journal:  Anat Embryol (Berl)       Date:  1996-09

9.  Immunohistological study on collagen in cartilage-bone metamorphosis and degenerative osteoarthrosis.

Authors:  S Gay; P K Müller; C Lemmen; K Remberger; K Matzen; K Kühn
Journal:  Klin Wochenschr       Date:  1976-10-15

10.  Chemical composition of normal and osteoarthrotic cancellous bone of the femoral head. Studies of EDTA extracts and collagenase digests.

Authors:  J M Mbuyi-Muamba; J Dequeker
Journal:  Arch Orthop Trauma Surg       Date:  1984
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