Literature DB >> 4724481

Stimulus-coupled secretion of gamma-aminobutyric acid from rat brain synaptosomes.

W B Levy, D A Redburn, C W Cotman.   

Abstract

Synaptosomes treated with radioactive gamma-aminobutyric acid can be stimulated to release this substance. The release is maximal within 40 seconds after stimulation and is dependent on calcium. Magnesium and manganese ions, known to block stimulus-secretion coupling processes, depress calcium-dependent release. This release is specific to synaptosomes because microsomal or myelin fractions do not release accumulated gamma-aminobutyric acid. The data illustrate a simple in vitro system suitable for analysis of secretion of gamma-aminobutyric acid in brain and in addition describe several new aspects of uptake and secretion of this compound at brain nerve endings.

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Year:  1973        PMID： 4724481     DOI： 10.1126/science.181.4100.676

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  10 in total

Review 1.  Genetics of neoplasia--impact of ecogenetics on oncogenesis. A review.

Authors:  D T Purtilo; L Paquin; T Gindhart
Journal:  Am J Pathol       Date:  1978-06       Impact factor: 4.307

2.  Differences in alkaline earth stimulation of neurotransmitter release from isolated brain synaptosomes.

Authors:  J W Haycock; W F White; C W Cotman
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978 Jan-Feb       Impact factor: 3.000

3.  Effect of calcium on Na-K-ATPase activity in depolarized rat cortical synaptosomes as determined on the basis of oxygen consumption.

Authors:  M Kálmán
Journal:  Exp Brain Res       Date:  1985       Impact factor: 1.972

4.  Characterization of the carrier-mediated [3H]GABA release from isolated synaptic plasma membrane vesicles.

Authors:  P P Gonçalves; A P Carvalho
Journal:  Neurochem Res       Date:  1995-02       Impact factor: 3.996

Review 5.  Pharmacology of GABA-mediated inhibition of spinal cord neurons in vivo and in primary dissociated cell culture.

Authors:  R L Macdonald; A B Young
Journal:  Mol Cell Biochem       Date:  1981-08-11       Impact factor: 3.396

6.  Effects of antidepressants on the uptake and release of norepinephrine from rat cerebral cortex.

Authors:  J Rubinstein-Kawamoto; J M Davis; G N Pandey
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

7.  On the functional coupling of neurotransmitter uptake and release in brain.

Authors:  C W Cotman; J W Haycock; W B Levy
Journal:  Br J Pharmacol       Date:  1976-12       Impact factor: 8.739

8.  Stimulus-secretion coupling processes in brain: analysis of noradrenaline and gamma-aminobutyric acid release.

Authors:  C W Cotman; J W Haycock; W F White
Journal:  J Physiol       Date:  1976-01       Impact factor: 5.182

9.  Properties of LHRH release from a hypothalamic synaptosomal fraction of estrogen-primed ovariectomized rats.

Authors:  M Tytell; J H Clark; E J Peck
Journal:  Neurochem Res       Date:  1980-05       Impact factor: 3.996

10.  Release of serotonin from nerve endings byL-5-hydroxytryptophan,α-methyl-m-tyramine, and elevated potassium ions.

Authors:  W J McBride; M H Aprison
Journal:  Neurochem Res       Date:  1976-06       Impact factor: 3.996
  10 in total

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