| Literature DB >> 4723802 |
J Lancaster, P R Sawyer, D M Shepherd, M J Turnbull.
Abstract
1. L-DOPA was administered to rats by twice daily intraperitoneal injection for a period of eleven days. The daily dose was gradually increased from 250 mg/kg to 1 g/kg. The animals were killed 12 h after the last injection and tissue catechol-O-methyl transferase, DOPA-decarboxylase and monoamine oxidase activity determined.2. Catechol-O-methyl transferase activity was reduced in the liver (46%) and red blood cells (38%) but was approximately doubled in the heart.3. Liver DOPA-decarboxylase activity was reduced by approximately 25%.4. L-DOPA administration did not significantly affect the activity of any of the enzymes studied in brain tissue.Entities:
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Year: 1973 PMID： 4723802 PMCID： PMC1776083 DOI： 10.1111/j.1476-5381.1973.tb08211.x
Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739