Literature DB >> 4722444

Inhibition by acetaldehyde of the pyruvate dehydrogenase complex from ox brain and ox kidney.

J P Blass, C A Lewis.   

Abstract

Low concentrations of acetaldehyde, similar to those that can occur in the brain of ethanol-treated animals, effectively inhibit the pyruvate dehydrogenase complex purified from ox brain or from ox kidney, although the precise mechanism of this inhibition remains to be defined.

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Year:  1973        PMID： 4722444      PMCID： PMC1177482          DOI： 10.1042/bj1310415

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  8 in total

1.  Evidence for a two-site mechanism for decarboxylation of alpha-keto acids by alpha-carboxylase.

Authors:  E JUNI
Journal:  J Biol Chem       Date:  1961-08       Impact factor: 5.157

2.  The occurrence of acetaldehyde in various parts of rat brain after alcohol injection, and its effect on pyruvate oxidation.

Authors:  K H KIESSLING
Journal:  Exp Cell Res       Date:  1962-08       Impact factor: 3.905

Review 3.  Biologic concomitants of alcoholism. 1.

Authors:  J H Mendelson
Journal:  N Engl J Med       Date:  1970-07-02       Impact factor: 91.245

4.  Effects of ethanol on glucose utilization in rat brain.

Authors:  E V Flock; G M Tyce; C A Owen
Journal:  Proc Soc Exp Biol Med       Date:  1970-11

5.  Effects of aliphatic alcohols and aldehydes on the metabolism of potassium-stimulated rat brain cortex slices.

Authors:  E Majchrowicz
Journal:  Can J Biochem       Date:  1965-07

6.  Kinetic properties of the partially purified pyruvate dehydrogenase complex of ox brain.

Authors:  J P Blass; C A Lewis
Journal:  Biochem J       Date:  1973-01       Impact factor: 3.857

7.  A defect in pyruvate decarboxylase in a child with an intermittent movement disorder.

Authors:  J P Blass; J Avigan; B W Uhlendorf
Journal:  J Clin Invest       Date:  1970-03       Impact factor: 14.808

8.  An inherited defect affecting the tricarboxylic acid cycle in a patient with congenital lactic acidosis.

Authors:  J P Blass; J D Schulman; D S Young; E Hom
Journal:  J Clin Invest       Date:  1972-07       Impact factor: 14.808
  8 in total
  1 in total

1.  Inhibition effects of furfural on alcohol dehydrogenase, aldehyde dehydrogenase and pyruvate dehydrogenase.

Authors:  Tobias Modig; Gunnar Lidén; Mohammad J Taherzadeh
Journal:  Biochem J       Date:  2002-05-01       Impact factor: 3.857
  1 in total

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