Literature DB >> 4722436

Palmitoyl-coenzyme A synthetase. Mechanism of reaction.

J Bar-Tana, G Rose, R Brandes, B Shapiro.   

Abstract

The mechanism of long-chain fatty acid activation catalysed by highly purified microsomal palmitoyl-CoA synthetase was investigated. The kinetics of the overall reaction were found to conform to the Bi Uni Uni Bi Ping Pong mechanism. (18)O was transferred from [(18)O]palmitate to AMP and palmitoyl-CoA exclusively. The enzyme intermediate formed appeared to consist of enzyme-bound palmitate; this formation occurred only in the presence of ATP. However, the involvement of palmitoyl-AMP in the reaction catalysed by the purified enzyme has proved difficult to establish.

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Year:  1973        PMID： 4722436      PMCID： PMC1177459          DOI： 10.1042/bj1310199

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  7 in total

1.  The kinetics of enzyme-catalyzed reactions with two or more substrates or products. III. Prediction of initial velocity and inhibition patterns by inspection.

Authors:  W W CLELAND
Journal:  Biochim Biophys Acta       Date:  1963-02-12

2.  The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations.

Authors:  W W CLELAND
Journal:  Biochim Biophys Acta       Date:  1963-01-08

3.  Mechanism of glutamic acid activation and glutamine synthesis.

Authors:  A MEISTER; P R KRISHNASWAMY; V PAMILJANS
Journal:  Fed Proc       Date:  1962 Nov-Dec

4.  A relation between non-esterified fatty acids in plasma and the metabolism of glucose.

Authors:  V P DOLE
Journal:  J Clin Invest       Date:  1956-02       Impact factor: 14.808

5.  Determination of 18 O content of phosphate compounds--a novel method.

Authors:  J Bar-Tana; O Ben-Zeev; G Rose; J Deutsh
Journal:  Biochim Biophys Acta       Date:  1972-03-30

6.  The purification and properties of microsomal palmitoyl-coenzyme A synthetase.

Authors:  J Bar-Tana; G Rose; B Shapiro
Journal:  Biochem J       Date:  1971-04       Impact factor: 3.857

7.  Microsomal palmitoyl coenzyme A synthetase from rat liver. Partial and exchange reactions.

Authors:  J Bar-Tana; G Rose; B Shapiro
Journal:  Biochem J       Date:  1972-10       Impact factor: 3.857
  7 in total
  10 in total

1.  Palmitoyl-coenzyme A synthetase. Isolation of an enzyme-bound intermediate.

Authors:  J Bar-Tana; G Rose; B Shapiro
Journal:  Biochem J       Date:  1973-11       Impact factor: 3.857

2.  Human intestinal acyl-CoA synthetase 5 is sensitive to the inhibitor triacsin C.

Authors:  Elke Kaemmerer; Anne Peuscher; Andrea Reinartz; Christian Liedtke; Ralf Weiskirchen; Jürgen Kopitz; Nikolaus Gassler
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3.  Functional characterization of the acyl-[acyl carrier protein] ligase in the Cryptosporidium parvum giant polyketide synthase.

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Journal:  Int J Parasitol       Date:  2006-11-27       Impact factor: 3.981

4.  Acyl coenzyme A synthetase from Pseudomonas fragi catalyzes the synthesis of adenosine 5'-polyphosphates and dinucleoside polyphosphates.

Authors:  R Fontes; M A Sillero; A Sillero
Journal:  J Bacteriol       Date:  1998-06       Impact factor: 3.490

5.  Rat liver microsomal palmitoyl-coenzyme A synthetase. Structural properties.

Authors:  J Bar-Tana; G Rose
Journal:  Biochem J       Date:  1973-03       Impact factor: 3.857

6.  Computer simulation of metabolism in palmitate-perfused rat heart. I. Palmitate oxidation.

Authors:  M C Kohn; D Garfinkel
Journal:  Ann Biomed Eng       Date:  1983       Impact factor: 3.934

7.  Mechanistic studies of the long chain acyl-CoA synthetase Faa1p from Saccharomyces cerevisiae.

Authors:  Hong Li; Elaina M Melton; Steven Quackenbush; Concetta C DiRusso; Paul N Black
Journal:  Biochim Biophys Acta       Date:  2007-06-12

8.  Arabidopsis contains a large superfamily of acyl-activating enzymes. Phylogenetic and biochemical analysis reveals a new class of acyl-coenzyme a synthetases.

Authors:  Jay M Shockey; Martin S Fulda; John Browse
Journal:  Plant Physiol       Date:  2003-06       Impact factor: 8.340

9.  Bioinformatic Analysis of Leishmania donovani Long-Chain Fatty Acid-CoA Ligase as a Novel Drug Target.

Authors:  Jaspreet Kaur; Rameshwar Tiwari; Arun Kumar; Neeloo Singh
Journal:  Mol Biol Int       Date:  2011-07-19

10.  TRPV1 channels as a newly identified target for vitamin D.

Authors:  Wentong Long; Janyne Johnson; Subha Kalyaanamoorthy; Peter Light
Journal:  Channels (Austin)       Date:  2021-12       Impact factor: 2.581
  10 in total

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