Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Contrasting oxygen-effects in the inactivation of ribonuclease A by N.3, (SCN).-2 and .OH radicals.

Literature DB >> 472108

Contrasting oxygen-effects in the inactivation of ribonuclease A by N.3, (SCN).-2 and .OH radicals.

Abstract

N.3 exhibits higher efficiency than .OH in the inactivation of RNase in de-acerated (neutral) aqueous solution. In O2-saturated solution the .OH-induced inactivation is enhanced, but N.3 and (SCN).-2 become remarkably inefficient. Our results suggest that semi-oxidized tyrosine, the predominant initial defect induced by N.3 and (SCN).-2 but not by .OH2 can be re-reduced upon reaction with O.-2 or cysteine.

Entities: Chemical

Mesh：

Substances：

Year: 1979 PMID： 472108 DOI： 10.1007/bf01326895

Source DB: PubMed Journal: Radiat Environ Biophys ISSN： 0301-634X Impact factor: 1.925

Keyword Cloud
References

11 in total

1. Inactivation of ribonuclease by the primary aqueous radicals.

Authors: L K Mee; S J Adelstein; G Stein
Journal: Radiat Res Date: 1972-12 Impact factor: 2.841

2. Selective free radical reactions with proteins and enzymes: the inactivation of ribonuclease.

Authors: G E Adams; R H Bisby; R B Cundall; J L Redpath; R L Willson
Journal: Radiat Res Date: 1972-02 Impact factor: 2.841

3. Selective free radical reactions with proteins and enzymes: reactions of inorganic radical anions with amino acids.

Authors: G E Adams; J E Aldrich; R H Bisby; R B Cundall; J L Redpath; R L Willson
Journal: Radiat Res Date: 1972-02 Impact factor: 2.841

4. Fast consecutive radical processes within the ribonuclease molecule in aqueous solution. II. Reaction with OH radicals and hydrated electrons.

Authors: N N Lichtin; J Ogdan; G Stein
Journal: Biochim Biophys Acta Date: 1972-07-13

Contrasting oxygen-effects in the inactivation of ribonuclease A by N.3, (SCN).-2 and .OH radicals.

1. Inactivation of ribonuclease by the primary aqueous radicals.

2. Selective free radical reactions with proteins and enzymes: the inactivation of ribonuclease.

3. Selective free radical reactions with proteins and enzymes: reactions of inorganic radical anions with amino acids.

4. Fast consecutive radical processes within the ribonuclease molecule in aqueous solution. II. Reaction with OH radicals and hydrated electrons.

5. On the mechanism of the radiation-induced inactivation of ribonuclease in dilute aqueous solution.

6. The radiolysis of dilute solutions of lysozyme. II. Pulse radiolysis studies with cysteine and oxygen.

Review 7. Photochemical inactivation of enzymes.

8. Reaction of azide radicals with amino acids and proteins.

9. Radiation chemistry of amino acids and peptides in aqueous solutions.

10. Chain reactions and radiosensitization: model enzyme studies.