Literature DB >> 4719215

A double isotope technique for the evaluation of drug action on gastric evacuation and small bowel propulsion studied in the rat.

F Nilsson, H Johansson.   

Abstract

A method to measure simultaneously gastric evacuation and small bowel propulsion in the rat is presented. The value of the method in testing drug action is described. The effect of an antidiarrhoeal agent, diphenoxylate, was analysed and it was shown that it retarded small bowel propulsion without influencing gastric evacuation.

Entities:  

Mesh：

Substances：

Year:  1973        PMID： 4719215      PMCID： PMC1412745          DOI： 10.1136/gut.14.6.475

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  5 in total

1.  ENDORADIOSONDE STUDY OF PROPULSION AND PRESSURE ACTIVITY INDUCED BY TEST MEALS, PROSTIGMINE, AND DIPHENOXYLATE IN THE SMALL INTESTINE.

Authors:  F BARANY; B JACOBSON
Journal:  Gut       Date:  1964-02       Impact factor: 23.059

2.  Synthetic antidiarrhoeal agents--I. Some pharmacological properties of R 1132 and related compounds.

Authors:  P A JANSSEN; A H JAGENEAU; J HUYGENS
Journal:  J Med Pharm Chem       Date:  1959-08

3.  Small bowel propulsive motility in the rat. Studies with open and closed pylorus.

Authors:  F Nilsson
Journal:  Acta Chir Scand       Date:  1972

4.  Gastric emptying and propulsive intestinal motility following partial gastric resection, gastro-enteroanastomosis, and abdominal "trunk" vagotomy in the rat.

Authors:  G Nylander; S Wikström
Journal:  Acta Chir Scand       Date:  1967

5.  Difenoxine (R 15403), the active metabolite of diphenoxylate (R 1132). 4. Distribution in the rat of diphenoxylate and difenoxine.

Authors:  J J Heykants; P J Lewi; P A Janssen
Journal:  Arzneimittelforschung       Date:  1972-03
  5 in total
  2 in total

1.  Sustained gastrointestinal activity of dendronized polymer-enzyme conjugates.

Authors:  Gregor Fuhrmann; Andrea Grotzky; Ružica Lukić; Simon Matoori; Paola Luciani; Hao Yu; Baozhong Zhang; Peter Walde; A Dieter Schlüter; Marc A Gauthier; Jean-Christophe Leroux
Journal:  Nat Chem       Date:  2013-06-09       Impact factor: 24.427

2.  Influence of orocaecal transit time on hydrogen excretion after carbohydrate malabsorption.

Authors:  J J Rumessen; O Hamberg; E Gudmand-Høyer
Journal:  Gut       Date:  1989-06       Impact factor: 23.059
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.