The effect of glucagon on serum gastrin. I. Studies in normal subjects.

Serum gastrin has been determined by radioimmunoassay in 13 subjects free of gastrointestinal disease, in the basal state, and following the intravenous injection of 1 mg glucagon. Serum gastrin fell from a mean +/- SEM level of 50.3 +/- 6.7 to 9.4 +/- 3.3 pg/ml at 30 minutes after injection, significant at p<0.005. This is similar to the response previously reported for secretin and indicates a role for glucagon in the control of gastrin release.