Literature DB >> 4718923

Induction of viral interference: effects of poly rI-rC and diethylaminoethyl-dextran on the activity of the antiviral protein.

J Kalmakoff, F J Austin.   

Abstract

The activity of the antiviral protein induced by various ratios of poly rI.rC and diethylaminoethyl (DEAE)-dextran was studied. It was found that, when large doses of poly rI.rC were used, very little viral interference was observed. This effect was initially attributed to the cells being refractory for production of antiviral protein. Subsequent experiments offered alternative explanations suggesting that, at any given dosage of poly rI.rC, an excess of DEAE-dextran is necessary for the production of viral interference. It is suggested that DEAE-dextran acts by exposing a cell receptor site for poly rI.rC.

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Year:  1973        PMID： 4718923      PMCID： PMC422810          DOI： 10.1128/iai.8.1.63-67.1973

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  20 in total

1.  Thermal activation of the antiviral activity of synthetic polyribonucleotides: influence of DEAE-dextran in various cell cultures.

Authors:  E De Clercq
Journal:  J Gen Virol       Date:  1971-02       Impact factor: 3.891

2.  The uptake of SV40 DNA by nonpermissive cells in the presence of DEAE-dextran.

Authors:  B V Howard; M K Estes; J S Pagano
Journal:  Biochim Biophys Acta       Date:  1971-01-01

3.  Two mechanisms of cell resistance to repeated stimulation of interferon.

Authors:  G H Bausek; T C Merigan
Journal:  Proc Soc Exp Biol Med       Date:  1970-07

4.  The refractory state after induction of interferon with double-stranded RNA.

Authors:  A Billiau
Journal:  J Gen Virol       Date:  1970-06       Impact factor: 3.891

5.  Diethylaminoethyl-dextran enhancement of interferon induction by a complexed polyribonucleotide.

Authors:  J G Tilles
Journal:  Proc Soc Exp Biol Med       Date:  1970-04

6.  Inducers of interferon and host resistance. 3. Double-stranded RNA from reovirus type 3 virions (reo 3-RNA).

Authors:  A A Tytell; G P Lampson; A K Field; M R Hilleman
Journal:  Proc Natl Acad Sci U S A       Date:  1967-10       Impact factor: 11.205

7.  Inhibition of interferon action by actinomycin.

Authors:  J Taylor
Journal:  Biochem Biophys Res Commun       Date:  1964       Impact factor: 3.575

8.  Control of interferon synthesis: effect of diethylaminoethyl-dextran on induction by polyinosinic-polycytidylic acid.

Authors:  J Vilcek; S L Barmak; E A Havell
Journal:  J Virol       Date:  1972-10       Impact factor: 5.103

9.  The specificity of interferon induction in chick embryo cells by helical RNA.

Authors:  C Colby; M J Chamberlin
Journal:  Proc Natl Acad Sci U S A       Date:  1969-05       Impact factor: 11.205

10.  [Interferon induction increased through chemical modification of a synthetic polyribonucleotide].

Authors:  E De Clercq; E Eckstein; T C Merigan
Journal:  Science       Date:  1969-09-12       Impact factor: 47.728
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  1 in total

1.  Effects of ionenes on interferon induction by poly(inosinic acid) . poly(cytidylic acid).

Authors:  E D Clercq; B Janik; R G Sommer
Journal:  Antimicrob Agents Chemother       Date:  1977-04       Impact factor: 5.191
  1 in total

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