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Literature DB >> 4717848

Reduction of absorption of paracetamol by activated charcoal and cholestyramine: a possible therapeutic measure.

B Dordoni, R A Willson, R P Thompson, R Williams.

Abstract

The absorption of an oral 2-g dose of paracetamol was markedly reduced by the simultaneous oral administration of either activated charcoal or cholestyramine but was only slightly reduced when the adsorbents were given 60 minutes after the paracetamol. Since the absorption of a larger dose of the drug will probably be slow, the administration of adsorbents may be of value even when delayed several hours.

Entities: Chemical

Mesh：

Substances：

Year: 1973 PMID： 4717848 PMCID： PMC1586518 DOI： 10.1136/bmj.3.5871.86

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

11 in total

1. The absorption characteristics of paracetamol tablets in man.

Authors: J R GWILT; A ROBERTSON; L GOLDMAN; A W BLANCHARD
Journal: J Pharm Pharmacol Date: 1963-07 Impact factor: 3.765

2. Gastrointestinal pharmacology of antipyretic-analgetic agents. II. Absorption and smooth muscle effects.

Authors: J H WEIKEL; P M LISH
Journal: Arch Int Pharmacodyn Ther Date: 1959-04-01

3. Plasma levels after the oral administration of acetylsalicylic acid and N-acetyl-p-aminophenol in different forms to human subjects.

Authors: P E CARLO; N M CAMBOSOS; G C FEENEY; P K SMITH
Journal: J Am Pharm Assoc Am Pharm Assoc Date: 1955-07

4. Some factors affecting the absorption of paracetamol.

Authors: I J McGilveray; G L Mattok
Journal: J Pharm Pharmacol Date: 1972-08 Impact factor: 3.765

5. Hepatic damage and death from overdose of paracetamol.

Authors: R Clark; V Borirakchanyavat; A R Davidson; R P Thompson; B Widdop; R Goulding; R Williams
Journal: Lancet Date: 1973-01-13 Impact factor: 79.321

6. The dependence of paracetamol absorption on the rate of gastric emptying.

Authors: R C Heading; J Nimmo; L F Prescott; P Tothill
Journal: Br J Pharmacol Date: 1973-02 Impact factor: 8.739

7. Absorption kinetics of aspirin in man following oral administration of an aqueous solution.

Authors: M Rowland; S Riegelman; P A Harris; S D Sholkoff
Journal: J Pharm Sci Date: 1972-03 Impact factor: 3.534

8. Effect of activated charcoal on aspirin absorption in man. Part I.

Authors: G Levy; T Tsuchiya
Journal: Clin Pharmacol Ther Date: 1972 May-Jun Impact factor: 6.875

9. Acute paracetamol poisoning.

Authors: A T Proudfoot; N Wright
Journal: Br Med J Date: 1970-09-05

10. Pharmacological modification of gastric emptying: effects of propantheline and metoclopromide on paracetamol absorption.

Authors: J Nimmo; R C Heading; P Tothill; L F Prescott
Journal: Br Med J Date: 1973-03-10

37 in total

Review 1. Simple analgesics.

Authors: J Parkhouse
Journal: Drugs Date: 1975 Impact factor: 9.546

Reduction of absorption of paracetamol by activated charcoal and cholestyramine: a possible therapeutic measure.

1. The absorption characteristics of paracetamol tablets in man.

2. Gastrointestinal pharmacology of antipyretic-analgetic agents. II. Absorption and smooth muscle effects.

3. Plasma levels after the oral administration of acetylsalicylic acid and N-acetyl-p-aminophenol in different forms to human subjects.

4. Some factors affecting the absorption of paracetamol.

5. Hepatic damage and death from overdose of paracetamol.

6. The dependence of paracetamol absorption on the rate of gastric emptying.

7. Absorption kinetics of aspirin in man following oral administration of an aqueous solution.

8. Effect of activated charcoal on aspirin absorption in man. Part I.

9. Acute paracetamol poisoning.

10. Pharmacological modification of gastric emptying: effects of propantheline and metoclopromide on paracetamol absorption.

Review 1. Simple analgesics.

2. Bioavailability of different preparations of paracetamol.

3. Charcoal haemoperfusion for paracetamol overdose.

Review 4. A comparative review of the adverse effects of treatments for hyperlipidaemia.

5. Plasma paracetamol estimation.

6. Macrophage electrophoretic mobility test.

7. 2-Hydroxyethyl methacrylate for sectioning bone marrow.

8. Oral ciprofloxacin affects the pharmacokinetics of paracetamol in saliva.

9. Comparative antidotal efficacy of activated charcoal tablets, capsules and suspension in healthy volunteers.

Review 10. Drug absorption in gastrointestinal disease with particular reference to malabsorption syndromes.