Literature DB >> 4717023

The effects of diphenylhydantoin and potassium on the biological activity of ouabain in the guinea-pig heart.

S I Baskin, S Dutta, B H Marks.   

Abstract

1. Diphenylhydantoin (DPH) and potassium significantly prevent ouabain intoxication without preventing the inotropic effects of ouabain in the guinea-pig isolated heart.2. The antiarrhythmic effect of DPH and K on ouabain-induced toxicity appears to be related to their ability to reduce ouabain accumulation by the myocardium and thereby prevent the intracellular Na and K changes which lead to the arrhythmic state.

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Year:  1973        PMID： 4717023      PMCID： PMC1776525          DOI： 10.1111/j.1476-5381.1973.tb08161.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  19 in total

1.  The effect of diphenylhydantoin administration on sodium-potassium-activated ATPase in cortex.

Authors:  E Lewin; V Bleck
Journal:  Neurology       Date:  1971-06       Impact factor: 9.910

2.  The action of diphenylhydantoin upon drug binding, ionic effects and inotropic action of ouabain.

Authors:  T Godfraind; M Lesne; A Pousti
Journal:  Arch Int Pharmacodyn Ther       Date:  1971-05

Review 3.  The current status of diphenylhydantoin in heart disease.

Authors:  E N Mercer; J A Osborne
Journal:  Ann Intern Med       Date:  1967-11       Impact factor: 25.391

4.  Mode of action of new anti-arrhythmic agents.

Authors:  T Sano; F Suzuki; S Sato; Y Iida
Journal:  Jpn Heart J       Date:  1968-03

5.  Factors that regulate ouabain-H3 accumulation by the isolated guinea-pig heart.

Authors:  S Dutta; B H Marks
Journal:  J Pharmacol Exp Ther       Date:  1969-12       Impact factor: 4.030

6.  Effect of several new antiarrhythmic agents on atrial contractility.

Authors:  B G Covino; C M Shannon
Journal:  Arch Int Pharmacodyn Ther       Date:  1969-03

7.  [On the effect of phenytoin on digitalis-precipitated arrhythmias].

Authors:  H Lüllmann; R Weber
Journal:  Arztl Forsch       Date:  1968-02-10

8.  Dissociation of the effects of digitalis on myocardial potassium flux and contractility.

Authors:  B J Scherlag; R H Helfant; M A Ricciutti; A N Damato
Journal:  Am J Physiol       Date:  1968-11

9.  Protection from digitalis toxicity with the prophylactic use of diphenylhydantoin sodium. An arrhythmic-inotropic dissociation.

Authors:  R H Helfant; B J Scherlag; A N Damato
Journal:  Circulation       Date:  1967-07       Impact factor: 29.690

10.  Calcium flux and contractility in guinea pig atria.

Authors:  S WINEGRAD; A M SHANES
Journal:  J Gen Physiol       Date:  1962-01       Impact factor: 4.086
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  5 in total

Review 1.  Drug interactions with digitalis glycosides.

Authors:  P F Binnion
Journal:  Drugs       Date:  1978-05       Impact factor: 9.546

Review 2.  [Properties of the receptor for cardiac glycosides (author's transl)].

Authors:  E Erdmann; W Schoner
Journal:  Klin Wochenschr       Date:  1974-08-01

3.  Ouabain-receptor interactions in (Na+ plus K+)-ATPase preparations. IV. The molecular structure of different cardioactive steroids and other substances and their affinity to the glycoside receptor.

Authors:  E Erdmann; W Schoner
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

4.  alpha-Adrenergic, beta-adrenergic and cholinergic mechanisms for amylase secretion by rat parotid gland in vitro.

Authors:  B A Leslie; J W Putney; J M Sherman
Journal:  J Physiol       Date:  1976-09       Impact factor: 5.182

5.  Evidence against an involvement of Na+, K+-ATPase in antiarrhythmic mechanism of phenytoin.

Authors:  H M Rhee
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-06       Impact factor: 3.000
  5 in total

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