Literature DB >> 4717017

Comparison of effects of six cholinomimetic drugs on inhibition of uptake of 3 H-( )-noradrenaline by guinea-pig atria.

G S Allen, M J Rand, D F Story.   

Abstract

The effects of N,N-dimethyl-N'-phenyl-piperazinium (DMPP), 4-(m-chlorophenyl-carbamoyloxy) - 2 - butynyltrimethylammonium chloride (McN-A-343), pilocarpine, acetylcholine, methacholi-ne and nicotine in inhibiting the uptake of (3)H-(+/-)-noradrenaline by guinea-pig atria were compared. In concentrations of 1 x 10(-4)M, the percentage inhibitions were as follows: DMPP, 89.1%; McN-A-343, 78.7%; pilocarpine 43.5%; acetylcholine, 35.7%; methacholine, 32.9%; nicotine, 21.6%.

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Year:  1973        PMID: 4717017      PMCID: PMC1776528          DOI: 10.1111/j.1476-5381.1973.tb08172.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN: 0007-1188            Impact factor:   8.739


  6 in total

1.  Effects of the muscarinic agonist McN-A-343 on responses to sympathetic nerve stimulation in the rabbit ear artery.

Authors:  M J Rand; B Varma
Journal:  Br J Pharmacol       Date:  1971-11       Impact factor: 8.739

2.  A muscarinic mechanism inhibiting the release of noradrenaline from peripheral adrenergic nerve fibres by nicotinic agents.

Authors:  R Lindmar; K Löffelholz; E Muscholl
Journal:  Br J Pharmacol Chemother       Date:  1968-02

3.  The effects of cholinomimetic drugs on responses to sympathetic nerve stimulation and noradrenaline in the rabbit ear artery.

Authors:  M J Rand; B Varma
Journal:  Br J Pharmacol       Date:  1970-04       Impact factor: 8.739

4.  Modification by acetylcholine of the response of rat mesenteric arteries to sympathetic stimulation.

Authors:  K U Malik; G M Ling
Journal:  Circ Res       Date:  1969-07       Impact factor: 17.367

5.  Modification of the vascular response to isoprenaline by cholinomimetic drugs.

Authors:  T C Hamilton
Journal:  Br J Pharmacol       Date:  1971-06       Impact factor: 8.739

6.  Effects of McN-A-343 and DMPP on the uptake and release of 3 H-noradrenaline by guinea-pig atria.

Authors:  G S Allen; M J Rand; D F Story
Journal:  Br J Pharmacol       Date:  1972-07       Impact factor: 8.739

  6 in total
  2 in total

1.  Modulation by acetylcholine of adrenergic transmission in the rabbit ear artery.

Authors:  G S Allen; A B Glover; M W McCulloch; M J Rand; D F Story
Journal:  Br J Pharmacol       Date:  1975-05       Impact factor: 8.739

2.  Interaction between the inhibitory action of acetylcholine and the alpha-adrenoceptor autoinhibitory feedback system on release of [3H]-noradrenaline from rat atria and rabbit ear artery.

Authors:  R E Loiacono; M J Rand; D F Story
Journal:  Br J Pharmacol       Date:  1985-03       Impact factor: 8.739

  2 in total

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