Literature DB >> 4716506

Action of oral metoclopramide on the gastrooesophageal junction in man.

J B Dilawari, J J Misiewicz.   

Abstract

The effect of oral metoclopramide, 10 mg, was studied with intraluminal manometry in 20 patients suffering from symptoms of gastrooesophageal reflux. The drug increased cardiac sphincter pressure and the amplitude of oesophageal peristaltic waves, but gastric motility was stimulated in only half of the patients. The clinical value of these pharmacological effects should be confirmed in therapeutic trials.

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Year:  1973        PMID： 4716506      PMCID： PMC1412692     

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  4 in total

1.  Gastrointestinal actions of metoclopramide. An experimental study.

Authors:  H I Jacoby; D A Brodie
Journal:  Gastroenterology       Date:  1967-04       Impact factor: 22.682

2.  The effect of metoclopramide on the gastroesophageal junctional zone and the distal esophagus in man.

Authors:  P Heitmann; N Möller
Journal:  Scand J Gastroenterol       Date:  1970       Impact factor: 2.423

3.  Effects of metoclopramide on isolated guinea-pig colon. 2. Interference with ganglionic stimulant drugs.

Authors:  C Bianchi; L Beani; C Crema
Journal:  Eur J Pharmacol       Date:  1970       Impact factor: 4.432

4.  Gastrointestinal effects of metoclopramide in man. In vitro experiments with human smooth muscle preparations.

Authors:  M Eisner
Journal:  Br Med J       Date:  1968-12-14
  4 in total
  11 in total

1.  Reflux esophagitis.

Authors:  W J Dodds; W J Hogan; W N Miller
Journal:  Am J Dig Dis       Date:  1976-01

Review 2.  Some aspects of medical management of gastrointestinal disease. I.

Authors:  B W Badley
Journal:  Can Med Assoc J       Date:  1975-01-25       Impact factor: 8.262

3.  Clinical pharmacology and therapeutics of the oesophagus and the lower oesophageal sphincter.

Authors:  J J Misiewicz
Journal:  Postgrad Med J       Date:  1974-04       Impact factor: 2.401

4.  Effect of bethanechol on gastroesophageal reflux.

Authors:  W N Miller; K P Ganeshappa; W J Dodds; W J Hogan; R F Barreras; R C Arndorfer
Journal:  Am J Dig Dis       Date:  1977-03

5.  Amyloidosis mimics achalasia's effect on lower esophageal sphincter.

Authors:  J R Lefkowitz; D L Brand; M D Schuffler; W R Brugge
Journal:  Dig Dis Sci       Date:  1989-04       Impact factor: 3.199

6.  L-Dopa inhibits metoclopramide stimulation of the lower esophageal sphincter in man.

Authors:  H W Baumann; A L Sturdevant; R W McCallum
Journal:  Dig Dis Sci       Date:  1979-04       Impact factor: 3.199

Review 7.  Metoclopramide: a review of its pharmacological properties and clinical use.

Authors:  R M Pinder; R N Brogden; P R Sawyer; T M Speight; G S Avery
Journal:  Drugs       Date:  1976       Impact factor: 9.546

8.  Metoclopramide inhibits development of esophageal varices in rat model.

Authors:  M Ohta; M Hashizume; K Tanoue; K Ueno; K Komori; T Ishii; S Kitano; K Sugimachi
Journal:  Dig Dis Sci       Date:  1994-09       Impact factor: 3.199

9.  Effect of metoclopramide on normal and delayed gastric emptying in gastroesophageal reflux patients.

Authors:  S M Fink; R C Lange; R W McCallum
Journal:  Dig Dis Sci       Date:  1983-12       Impact factor: 3.199

10.  Cisapride restores the decreased lower oesophageal sphincter pressure in reflux patients.

Authors:  P Ceccatelli; J Janssens; G Vantrappen; S Cucchiara
Journal:  Gut       Date:  1988-05       Impact factor: 23.059
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