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Literature DB >> 471075

The affinity of atropine for muscarine receptors in human sphincter pupillae.

Abstract

Concentration-dependent contractions in response to carbachol were determined on isolated pieces of human iris. Atropine competivtively antagonized the effect of carbachol. An apparent dissociation equilibrium constant of 0.4--0.7 nM was estimated for the muscarine receptor-atropine complex.

Entities: Chemical Disease Species

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Year: 1979 PMID： 471075 DOI： 10.1007/bf00507105

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

7 in total

1. THE UPTAKE OF ATROPINE AND RELATED DRUGS BY INTESTINAL SMOOTH MUSCLE OF THE GUINEA-PIG IN RELATION TO ACETYLCHOLINE RECEPTORS.

Authors: W D PATON; H P RANG
Journal: Proc R Soc Lond B Biol Sci Date: 1965-08-24

2. A modification of receptor theory.

Authors: R P STEPHENSON
Journal: Br J Pharmacol Chemother Date: 1956-12

3. Factors determining the potency of mydriatic drugs in man.

Authors: S A Smith
Journal: Br J Clin Pharmacol Date: 1976-06 Impact factor: 4.335

4. The rate of action of atropine.

Authors: C D Thron; D R Waud
Journal: J Pharmacol Exp Ther Date: 1968-03 Impact factor: 4.030

5. Convenient apparatus for recording contractions of isolated heart muscle.

Authors: J R Blinks
Journal: J Appl Physiol Date: 1965-07 Impact factor: 3.531

6. Some quantitative uses of drug antagonists.

Authors: O ARUNLAKSHANA; H O SCHILD
Journal: Br J Pharmacol Chemother Date: 1959-03

7. A comparison of the affinities of antagonists for acetylcholine receptors in the ileum, bronchial muscle and iris of the guinea-pig.

Authors: R B Barlow; F M Franks; J D Pearson
Journal: Br J Pharmacol Date: 1972-10 Impact factor: 8.739

7 in total

5 in total

1. Receptor-responses in fresh human ciliary muscle.

Authors: M D Lograno; A Reibaldi
Journal: Br J Pharmacol Date: 1986-02 Impact factor: 8.739

2. Muscarinic inhibition of [3H]-noradrenaline release on rabbit iris in vitro: effects of stimulation conditions on intrinsic activity of methacholine and pilocarpine.

Authors: I T Bognar; S Pallas; H Fuder; E Muscholl
Journal: Br J Pharmacol Date: 1988-07 Impact factor: 8.739