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Literature DB >> 4706806

Effect of orally administered prostaglandin E 2 and its 15-methyl analogues on gastric secretion.

S M Karim, D C Carter, D Bhana, P A Ganesan.

Abstract

The effect of orally administered prostaglandin E(2) and its synthetic 15-methyl analogues on gastric secretion in man was studied. The parent E(2) compound did not inhibit basal secretion, whereas both the 15 (S) 15-methyl-E(2) methyl ester and its isomer, 15 (R) 15-methyl-E(2) methyl ester inhibited basal acid secretion. This action is likely to be a direct one on the parietal cell, and it could prove of value in the treatment of peptic ulcer.

Entities: Chemical Disease Species

Mesh：

Substances：
Esters
Prostaglandins

Year: 1973 PMID： 4706806 PMCID： PMC1588413 DOI： 10.1136/bmj.1.5846.143

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

15 in total

1. Comparison of prostaglandin E1 and norepinephrine on the gastric mucosal circulation.

Authors: E D Jacobson
Journal: Proc Soc Exp Biol Med Date: 1970-02

2. Inhibition of gastric acid secretion in vitro by prostaglandin E1.

Authors: L Way; R P Durbin
Journal: Nature Date: 1969-03-01 Impact factor: 49.962

Review 3. [Effects of prostaglandin on the function of the gastric secretion].

Authors: T Wada; M Ishizawa
Journal: Nihon Rinsho Date: 1970-10

4. Termination of second trimester pregnancy with 15 methyl analogues of prostaglandins E 2 and F 2 .

Authors: S M Karim; S D Sharma
Journal: J Obstet Gynaecol Br Commonw Date: 1972-08

5. (15S)-15-methylprostaglandins.

Authors: E W Yankee; G L Bundy
Journal: J Am Chem Soc Date: 1972-05-17 Impact factor: 15.419

6. Effect of prostaglandin E1 on gastric secretion and ulcer formation in the rat.

Authors: A Robert; J E Nezamis; J P Phillips
Journal: Gastroenterology Date: 1968-10 Impact factor: 22.682

7. Prostaglandin inhibition of gastric secretion.

Authors: P W Ramwell; J E Shaw
Journal: J Physiol Date: 1968-03 Impact factor: 5.182

8. Effect of orally administered prostaglandin E1 on gastric secretion and gastrointestinal motility in man.

Authors: E W Horton; I H Main; C J Thompson; P M Wright
Journal: Gut Date: 1968-12 Impact factor: 23.059

9. Effects of prostaglandin E2 (PGE2) on the output of histamine and acid in rat gastric secretion induced by pentagastrin or histamine.

Authors: I H Main
Journal: Br J Pharmacol Date: 1969-05 Impact factor: 8.739

10. Activity of 15[S] 15-methyl prostaglandin E2 and F2alpha as stimulants of uterine contractility.

Authors: K T Kirton; A D Forbes
Journal: Prostaglandins Date: 1972-04

30 in total

Review 1. Drugs in the treatment of gastric and duodenal ulcer.

Authors: M J Langman
Journal: Drugs Date: 1977-08 Impact factor: 9.546

2. Effect of methylated PGE2 analogs given orally on pancreatic response to secretin in man.

Authors: S J Konturek; N Kwiecień; J Swierczek; J Oleksy
Journal: Am J Dig Dis Date: 1977-01

3. Potency and selectivity of methyl analogues of prostaglandin E2 on rat gastrointestinal function.

Authors: I H Main; B J Whittle
Journal: Br J Pharmacol Date: 1975-07 Impact factor: 8.739

4. Serum immunoreactive gastrin: specificity for rheumatoid arthritis, bimodality of distribution, and failure of effect of anti-inflammatory drugs.

Authors: P J Rooney; D M Grennan; R D Sturrock; P M Brooks; W C Dick
Journal: Ann Rheum Dis Date: 1976-02 Impact factor: 19.103

5. Effect of the prostaglandin precursor, arachidonic acid, on histamine stimulated gastric secretion in the conscious dog, and observations on the effect of inhibiting endogenous prostaglandin synthesis.

Authors: M E Conolly; P R Bieck; N A Payne; B Adkins; J A Oates
Journal: Gut Date: 1977-06 Impact factor: 23.059