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Literature DB >> 4703227

In vitro myelosuppression and immunosuppression by ethanol.

Abstract

Concentrations of ethanol similar to those in the blood of intoxicated patients suppressed phytohemagglutinin- or streptolysin O-induced lymphocyte transformation, and inhibited bone marrow granulocyte colony growth in soft agar. Inhibition of lymphocyte transformation and granulocyte colony growth occurred despite the presence of large concentrations of folate and other vitamins. These in vitro findings may relate to in vivo effects of ethanol on myeloid and lymphoid tissue.

Entities: Chemical Disease Species

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Year: 1973 PMID： 4703227 PMCID： PMC302405 DOI： 10.1172/JCI107314

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

17 in total

1. Response of mouse T and B lymphocytes to sheep erythrocytes.

Authors: J H Playfair
Journal: Nat New Biol Date: 1972-01-26

2. Inhibition by penicillamine of DNA and protein synthesis by human bone marrow.

Authors: G Tisman; V Herbert; L T Go; L Brenner
Journal: Proc Soc Exp Biol Med Date: 1972-02

3. Thymus-marrow cell interaction evaluated by PHA stimulation and graft versus host activity.

Authors: G Tridente; G Biasi; L Chieco-Bianchi; L Fiore-Donati
Journal: Nature Date: 1971-11-12 Impact factor: 49.962

4. Differential effects of melphalan on mouse myeloma (adj. PC-5) and hemopoietic stem cells.

Authors: M Ogawa; D E Bergsagel; E A McCulloch
Journal: Cancer Res Date: 1971-12 Impact factor: 12.701

5. Thrombocytopenia in alcoholics.

Authors: J Lindenbaum; R L Hargrove
Journal: Ann Intern Med Date: 1968-03 Impact factor: 25.391

6. Effect of alcohol on the mobilization of alveolar macrophages.

Authors: J J Guarneri; G A Laurenzi
Journal: J Lab Clin Med Date: 1968-07

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Authors: J Metz; A Kelly; V C Swett; S Waxman; V Herbert
Journal: Br J Haematol Date: 1968-06 Impact factor: 6.998

8. Clony growth of human peripherl white blood cells in vitro.

Authors: J E Kurnick; W A Robison
Journal: Blood Date: 1971-02 Impact factor: 22.113

9. Release of vitamin B12--binding protein by human leukocytes in vitro.

Authors: J Corcino; S Krauss; S Waxman; V Herbert
Journal: J Clin Invest Date: 1970-12 Impact factor: 14.808

10. Specific heterologous enhancement of immune responses. II. Immunological memory cells of thymic origin.

Authors: A S Rubin; A H Coons
Journal: J Exp Med Date: 1972-02-01 Impact factor: 14.307

13 in total

Review 1. Alcohol abuse and disorder of granulopoiesis.

Authors: Xin Shi; Angelo L DeLucia; Jianxin Bao; Ping Zhang
Journal: Pharmacol Ther Date: 2019-03-01 Impact factor: 12.310

2. Effects of ethanol on rat Schwann cell proliferation and myelination in culture.

Authors: F A Mithen; M M Reiker; R Birchem
Journal: In Vitro Cell Dev Biol Date: 1990-02

3. Suppression of the stem cell antigen-1 response and granulocyte lineage expansion by alcohol during septicemia.

Authors: John N Melvan; Robert W Siggins; Gregory J Bagby; William L Stanford; David A Welsh; Steve Nelson; Ping Zhang
Journal: Crit Care Med Date: 2011-09 Impact factor: 7.598

4. Alcohol suppresses the granulopoietic response to pulmonary Streptococcus pneumoniae infection with enhancement of STAT3 signaling.

Authors: Robert W Siggins; John N Melvan; David A Welsh; Gregory J Bagby; Steve Nelson; Ping Zhang
Journal: J Immunol Date: 2011-02-28 Impact factor: 5.422

Review 5. Neutropenia during HIV infection: adverse consequences and remedies.

Authors: Xin Shi; Matthew D Sims; Michel M Hanna; Ming Xie; Peter G Gulick; Yong-Hui Zheng; Marc D Basson; Ping Zhang
Journal: Int Rev Immunol Date: 2014-03-21 Impact factor: 5.311

6. Stimulation by alcohols of cyclic AMP metabolism in human leukocytes. Possible role of cyclic AMP in the anti-inflammatory effects of ethanol.

Authors: J P Atkinson; T J Sullivan; J P Kelly; C W Parker
Journal: J Clin Invest Date: 1977-08 Impact factor: 14.808