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Literature DB >> 4701794

A trial of prophylactic replacement therapy in haemophilia and Christmas disease.

Abstract

A trial of prophylactic replacement therapy in low dosage once a week is described in two patients with classical haemophilia and one patient with Christmas disease, using concentrates of factor VIII and factor IX respectively. The clinical effectiveness and complications of the therapy are assessed and discussed. It was concluded that the patient suffering from Christmas disease showed both objective and subjective improvement while on prophylaxis and merited further study. Neither of the patients with haemophilia showed objective evidence of improvement, but both stated that they felt fitter and more able to lead a normal life while on the trial.

Entities: Disease Species

Mesh：

Substances：

Year: 1973 PMID： 4701794 PMCID： PMC477696 DOI： 10.1136/jcp.26.4.243

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

14 in total

Review 2. Clotting factor concentrates for preventing bleeding and bleeding-related complications in previously treated individuals with haemophilia A or B.

Authors: Omotola O Olasupo; Megan S Lowe; Ashma Krishan; Peter Collins; Alfonso Iorio; Davide Matino
Journal: Cochrane Database Syst Rev Date: 2021-08-18

2 in total

A trial of prophylactic replacement therapy in haemophilia and Christmas disease.

1. HIGH-POTENCY ANTIHAEMOPHILIC FACTOR CONCENTRATE PREPARED FROM CRYOGLOBULIN PRECIPITATE.

2. A one-stage factor VIII (antihaemophilic globulin) assay and its use on venous and capillary plasma.

3. Severe reactions after cryoprecipitated human factor VIII.

4. Dental extractions and the use of Christmas factor concentrate in cases of haemophilia B.

5. Prophylactic treatment of factor VIII deficiency.

6. Experimental prophylaxis of severe hemophilia with a factor VIII concentrate.

7. Preparation and clinical use of factor IX concentrate PPSB according to Soulier.

8. A clinical and experimental study of acquired inhibitors to factor 8.

9. Serum hepatitis antigen (SH): rapid detection by high voltage immunoelectroosmophoresis.

10. Prophylactic therapy in classical hemophilia: a preliminary report.

1. Twice weekly prophylactic therapy in haemophilia A.

Review 2. Clotting factor concentrates for preventing bleeding and bleeding-related complications in previously treated individuals with haemophilia A or B.