| Literature DB >> 47015 |
M J Hill, B S Drasar, R E Williams, T W Meade, A G Cox, J E Simpson, B C Morson.
Abstract
Of 44 patients with cancer of the large bowel, 36 ( 82%) had high faecal bile-acid concentrations compared with only 15 (17%) out of 90 patients with other diseases. 31 (70%) of the 44 patients with large-bowel cancer had high faecal bile-acid concentrations in the presence of faecal clostridia able to dehydrogenate the bile-acid nucleus, compared with only 8 (9%) out of 90 patients with other diseases. Thes findings support the hypothesis that cancer of the large bowel is caused by high concentrations of bile-acid derivatives produced by certain anaerobic bacteria.Entities:
Mesh：
Substances：
Year: 1975 PMID： 47015 DOI： 10.1016/s0140-6736(75)91556-1
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321