Literature DB >> 4700434

The effect of coeliac disease upon bile salts.

T S Low-Beer, K W Heaton, E W Pomare, A E Read.   

Abstract

The size and composition of the bile salt pool has been measured in patients with untreated coeliac disease and in control subjects. The total bile salt pool was markedly increased in coeliac patients, the average being 9.2 grams compared with 3.1 grams in controls. Taurocholate synthesis was normal, consistent with its enlarged pool and prolonged half-life. Half-life and pool size were significantly correlated. The composition of the bile salt pool was virtually identical in the two groups. Our findings suggest that as the enterohepatic circulation is slowed by gallbladder inertia, so hepatic surveillance of pool size is diminished.

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Year:  1973        PMID： 4700434      PMCID： PMC1412621          DOI： 10.1136/gut.14.3.204

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  11 in total

1.  Gallbladder inertia and sluggish enterohepatic circulation of bile-salts in coeliac disease.

Authors:  T S Low-Beer; K W Heaton; S T Heaton; A E Read
Journal:  Lancet       Date:  1971-05-15       Impact factor: 79.321

2.  Intestinal and faecal bile-acids in malabsorption.

Authors:  T A Miettinen
Journal:  Lancet       Date:  1968-08-10       Impact factor: 79.321

3.  Control of bile salt synthesis.

Authors:  T S Low-Beer; E W Pomare; J S Morris
Journal:  Nat New Biol       Date:  1972-08-16

4.  Impaired cholecystokinin-pancreozymin secretion, intraluminal dilution, and maldigestion of fat in sprue.

Authors:  E P DiMagno; W L Go; W H Summerskill
Journal:  Gastroenterology       Date:  1972-07       Impact factor: 22.682

5.  An evaluation of radiological signs in small bowel examinations in children.

Authors:  W D Jeans
Journal:  Clin Radiol       Date:  1972-01       Impact factor: 2.350

6.  Micellar solubilization of intestinal lipids and sterols in gluten enteropathy and liver cirrhosis.

Authors:  T A Miettinen; M Siurala
Journal:  Scand J Gastroenterol       Date:  1971       Impact factor: 2.423

7.  Enterohepatic circulation of C14-labeled bile salts in disorders of the distal small bowel.

Authors:  K W Heaton; W I Austad; L Lack; M P Tyor
Journal:  Gastroenterology       Date:  1968-07       Impact factor: 22.682

8.  Quantitative determination of the major 3-hydroxy bile acids in biological material after thin-layer chromatographic separation.

Authors:  A Bruusgaard
Journal:  Clin Chim Acta       Date:  1970-06       Impact factor: 3.786

9.  Importance of bile acids and of an intact distal small intestine for fat absorption.

Authors:  W I Austad; L Lack; M P Tyor
Journal:  Gastroenterology       Date:  1967-04       Impact factor: 22.682

10.  Metabolism of steroid and amino acid moieties of conjugated bile acids in man. II. Glycine-conjugated dihydroxy bile acids.

Authors:  G W Hepner; A F Hofmann; P J Thomas
Journal:  J Clin Invest       Date:  1972-07       Impact factor: 14.808
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  10 in total

1.  Biliary function studies in patients with celiac sprue.

Authors:  L O Colombato; H Parodi; D Cantor
Journal:  Am J Dig Dis       Date:  1977-02

2.  The control of bile acid pool size: effect of jejunal resection and phenobarbitone on bile acid metabolism in the rat.

Authors:  H Y Mok; P M Perry; R H Dowling
Journal:  Gut       Date:  1974-04       Impact factor: 23.059

3.  The effect of cholecystectomy on bile salt metabolism.

Authors:  E W Pomare; K W Heaton
Journal:  Gut       Date:  1973-10       Impact factor: 23.059

4.  Alteration of bile salt metabolism by dietary fibre (bran).

Authors:  E W Pomare; K W Heaton
Journal:  Br Med J       Date:  1973-11-03

5.  Hypocalcemia and steatorrhea--clues to etiology.

Authors:  J E Heubi; J C Partin; W K Schubert
Journal:  Dig Dis Sci       Date:  1983-02       Impact factor: 3.199

6.  Sulphated bile acids in duodenal juice of healthy infants and children compared with sulphated bile acids in paediatric patients with various gastroenterological diseases.

Authors:  K H Niessen; M Teufel; G Brügmann
Journal:  Gut       Date:  1984-01       Impact factor: 23.059

7.  Regulation of bile salt pool size in man.

Authors:  T S Low-Beer; E W Pomare
Journal:  Br Med J       Date:  1973-05-12

8.  Biliary lipids, bile acids, and gallbladder function in the human female. Effects of pregnancy and the ovulatory cycle.

Authors:  F Kern; G T Everson; B DeMark; C McKinley; R Showalter; W Erfling; D Z Braverman; P Szczepanik-van Leeuwen; P D Klein
Journal:  J Clin Invest       Date:  1981-11       Impact factor: 14.808

9.  Effects of a pharmacological dose of cholecystokinin on bile acid kinetics and biliary cholesterol saturation in man.

Authors:  R P Jazrawi; T C Northfield
Journal:  Gut       Date:  1986-04       Impact factor: 23.059

10.  Altered bile in diabetic diarrhoea.

Authors:  A M Molloy; G H Tomkin
Journal:  Br Med J       Date:  1978-11-25
  10 in total

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