Literature DB >> 4700009

Effects of clonidine withdrawal: possible mechanisms and suggestions for management.

S N Hunyor, L Hansson, T S Harrison, S W Hoobler.   

Abstract

A severe rebound rise in blood pressure with agitation and insomnia had been noted in five patients when they had previously ceased clonidine (Catapres) This has been shown to be reproducible in these patients and to be associated with a significant increase in urinary catecholamine excretion. The blood pressure can be controlled and the symptoms alleviated promptly by alpha and beta adrenergic receptor blockade using intravenous phentolamine and propranolol.

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Year:  1973        PMID： 4700009      PMCID： PMC1589404          DOI： 10.1136/bmj.2.5860.209

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  7 in total

1.  EFFECTS OF SMALL ORAL DOSES OF RESERPINE ON VASCULAR RESPONSES TO TYRAMINE AND NOREPINEPHRINE IN MAN.

Authors:  F M ABBOUD; J W ECKSTEIN
Journal:  Circulation       Date:  1964-02       Impact factor: 29.690

2.  Improved technique for the fluorimetric estimation of catecholamines.

Authors:  U von EULER; F LISHAJKO
Journal:  Acta Physiol Scand       Date:  1961-04

3.  Comparison of clonidine and methyldopa on blood pressure and side effects in hypertensive patients.

Authors:  M R Putzeys; S W Hoobler
Journal:  Am Heart J       Date:  1972-04       Impact factor: 4.749

4.  The use of "Catapres" in the treatment of severe hypertension.

Authors:  J Raftos
Journal:  Med J Aust       Date:  1969-10-04       Impact factor: 7.738

5.  Studies on catecholamines, renin and aldosterone following Catapresan (2-(2,6-dichlor-phenylamine)-2-imidazoline hydrochloride) in hypertensive patients.

Authors:  B Hökfelt; H Hedeland; J F Dymling
Journal:  Eur J Pharmacol       Date:  1970       Impact factor: 4.432

6.  Antihypertensive effect of a new imidazoline compound (clonidine) and chlorthalidone, individually and in combination.

Authors:  W B Parsons; J H Morledge
Journal:  Am J Cardiol       Date:  1970-09       Impact factor: 2.778

7.  Clinical observations on a new antihypertensive drug, 2-(2,6-dichlorphenylamine)-2-imidazoline hydrochloride.

Authors:  G Smet; S W Hoobler; S Sanbar; S Julis
Journal:  Am Heart J       Date:  1969-04       Impact factor: 4.749
  7 in total
  18 in total

1.  Rapid clonidine withdrawal with blood pressure overshoot exaggerated by beta-blockade.

Authors:  R R Bailey; T J Neale
Journal:  Br Med J       Date:  1976-04-17

2.  Clonidine overdose.

Authors:  S N Hunyor; K Bradstock; P J Somerville; N Lucas
Journal:  Br Med J       Date:  1975-10-04

3.  Problems with Beta Adrenergic Blocking Drugs and other Antihypertensive Drugs.

Authors:  B N Prichard
Journal:  Proc R Soc Med       Date:  1977

4.  Rebound phenomenon during gradual withdrawal of clonidine.

Authors:  R Vanholder; J Carpentier; M Schurgers; D L Clement
Journal:  Br Med J       Date:  1977-04-30

5.  Clonidine withdrawal induced sympathetic surge.

Authors:  Michael Shaw; Ramprasad Matsa
Journal:  BMJ Case Rep       Date:  2015-06-02

Review 6.  New drugs in hypertension.

Authors:  M G Myers
Journal:  Can Med Assoc J       Date:  1977-01-22       Impact factor: 8.262

7.  Failure of labetalol to prevent hypertension due to clonidine withdrawal.

Authors:  D M Hurley; R Vandongen; L J Beilin
Journal:  Br Med J       Date:  1979-04-28

8.  Antihypertensive drug therapy.

Authors:  F O Simpson
Journal:  Drugs       Date:  1973       Impact factor: 9.546

9.  Use of labetalol in hypertensive patients during discontinuation of clonidine therapy.

Authors:  T Rosenthal; B Rabinowitz; H Boichis; E Elazar; A Brauner; H N Neufeld
Journal:  Eur J Clin Pharmacol       Date:  1981       Impact factor: 2.953

10.  Double-blind trial comparing guanfacine and methyldopa in patients with essential hypertension.

Authors:  A J Bune; J P Chalmers; J R Graham; P R Howe; M J West; L M Wing
Journal:  Eur J Clin Pharmacol       Date:  1981       Impact factor: 2.953
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