Literature DB >> 469267

A single-step immunization by sustained antigen release.

I Preis, R S Langer.   

Abstract

An inert polymer pellet less than 1 mm in diameter, implanted subcutaneously in mice, releases free antigen continuously and enhances antibody formation for over 6 months. The immune response stimulated by sustained antigen delivery is comparable to the secondary response induced by the same total dose of antigen emulsified in complete Freund's adjuvant. The sustained release polymer implants, using antigens over a wide molecular weight range, proved effective in eliciting prolonged antibody formation. The antigens tested included bovine serum albumin, gamma-globulin, and ribonuclease. Superior biocompatibility and release characteristics make the ethylene-vinyl acetate copolymer a promising method for the single-step induction of immunity.

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Year:  1979        PMID： 469267     DOI： 10.1016/0022-1759(79)90341-7

Source DB:  PubMed          Journal:  J Immunol Methods        ISSN： 0022-1759            Impact factor:   2.303


  29 in total

1.  Controlled release of polypeptides and other macromolecules.

Authors:  R A Siegel; R Langer
Journal:  Pharm Res       Date:  1984-01       Impact factor: 4.200

2.  The pharmacokinetics of, and humoral responses to, antigen delivered by microencapsulated liposomes.

Authors:  S Cohen; H Bernstein; C Hewes; M Chow; R Langer
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-01       Impact factor: 11.205

3.  Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination.

Authors:  Hok Hei Tam; Mariane B Melo; Myungsun Kang; Jeisa M Pelet; Vera M Ruda; Maria H Foley; Joyce K Hu; Sudha Kumari; Jordan Crampton; Alexis D Baldeon; Rogier W Sanders; John P Moore; Shane Crotty; Robert Langer; Daniel G Anderson; Arup K Chakraborty; Darrell J Irvine
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-04       Impact factor: 11.205

4.  New age adjuvants and delivery systems for subunit vaccines.

Authors:  S Kurella; M Manocha; L Sabhnani; B Thomas; D N Rao
Journal:  Indian J Clin Biochem       Date:  2000-08

Review 5.  Beyond antigens and adjuvants: formulating future vaccines.

Authors:  Tyson J Moyer; Andrew C Zmolek; Darrell J Irvine
Journal:  J Clin Invest       Date:  2016-03-01       Impact factor: 14.808

Review 6.  Modulating the immune system through nanotechnology.

Authors:  Tamara G Dacoba; Ana Olivera; Dolores Torres; José Crecente-Campo; María José Alonso
Journal:  Semin Immunol       Date:  2017-10-09       Impact factor: 11.130

Review 7.  Immunopotentiation and delivery systems for antigens for single-step immunization: recent trends and progress.

Authors:  M Z Khan; J P Opdebeeck; I G Tucker
Journal:  Pharm Res       Date:  1994-01       Impact factor: 4.200

Review 8.  Engineering synthetic vaccines using cues from natural immunity.

Authors:  Darrell J Irvine; Melody A Swartz; Gregory L Szeto
Journal:  Nat Mater       Date:  2013-11       Impact factor: 43.841

9.  Polymer chemistry influences monocytic uptake of polyanhydride nanospheres.

Authors:  Bret D Ulery; Yashdeep Phanse; Avanti Sinha; Michael J Wannemuehler; Balaji Narasimhan; Bryan H Bellaire
Journal:  Pharm Res       Date:  2008-11-06       Impact factor: 4.200

10.  Vaccine adjuvants - Current status and prospects on controlled release adjuvancity.

Authors:  S M Sivakumar; Mohammed M Safhi; M Kannadasan; N Sukumaran
Journal:  Saudi Pharm J       Date:  2011-06-25       Impact factor: 4.330
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