Literature DB >> 469010

Reactogenicity and immunogenicity of a surface-antigen-adsorbed influenza virus vaccine in children.

L M Eastwood, R Jennings, R D Milner, C W Potter.   

Abstract

An influenza virus vaccine containing the purified surface haemagglutinin and neuraminidase antigens of A/Victoria/75 and B/Hong Kong/73 viruses adsorbed to an aluminium hydroxide gel was assessed for reactogenicity and immunogenicity in children aged 4 to 11 years, since there is no influenza virus vaccine available for this age group. Significant serum haemagglutination-inhibiting antibody responses to the A/Victoria/75 and B/Hong Kong/73 haemagglutinin antigens present in the vaccine were observed in 47% and 35%, respectively, of the children vaccinated, with a single dose. The vaccine induced no significant local or systemic reactions.

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Year:  1979        PMID： 469010      PMCID： PMC1145733          DOI： 10.1136/jcp.32.6.534

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  18 in total

1.  COMPARISONS OF SEROLOGIC AND FEBRILE RESPONSES IN HUMANS TO VACCINATION WITH INFLUENZA A VIRUSES OR THEIR HEMAGGLUTININS.

Authors:  F M DAVENPORT; A V HENNESSY; F M BRANDON; R G WEBSTER; C D BARRETT; G O LEASE
Journal:  J Lab Clin Med       Date:  1964-01

2.  Application of a microtechnique to viral serological investigations.

Authors:  J L SEVER
Journal:  J Immunol       Date:  1962-03       Impact factor: 5.422

3.  Human febrile response to influenza virus or its ether isolated hemagglutinins.

Authors:  F B Brandon; C D Barrett; A E Hook; G O Lease
Journal:  Proc Soc Exp Biol Med       Date:  1967-07

4.  Effect of neuraminidase antibody on Hong Kong influenza.

Authors:  A S Monto; A P Kendal
Journal:  Lancet       Date:  1973-03-24       Impact factor: 79.321

5.  Adverse reactions to 1975 bivalent influenza vaccine in children.

Authors:  S Schevill; M I Marks
Journal:  Can Med Assoc J       Date:  1977-02-05       Impact factor: 8.262

6.  Influenza vaccine: split-product versus whole-virus types--How do they differ.

Authors:  P A Gross; F A Ennis
Journal:  N Engl J Med       Date:  1977-03-10       Impact factor: 91.245

7.  Quantification of influenza virus structural proteins using rocket immunoelectrophoresis.

Authors:  J S Oxford; G C Schild
Journal:  J Gen Virol       Date:  1978-01       Impact factor: 3.891

8.  A controlled double-blind comparison of reactogenicity, immunogenicity, and protective efficacy of whole-virus and split-product influenza vaccines in children.

Authors:  P A Gross; F A Ennis; P F Gaerlan; L J Denson; C R Denning; D Schiffman
Journal:  J Infect Dis       Date:  1977-11       Impact factor: 5.226

9.  A surface antigen influenza vaccine. 1. Purification of haemagglutinin and neuraminidase proteins.

Authors:  M I Brady; I G Furminger
Journal:  J Hyg (Lond)       Date:  1976-10

10.  Dose-response relationship after immunization of volunteers with a new, surface-antigen-adsorbed influenza virus vaccine.

Authors:  C W Potter; R Jennings; J P Phair; A Clarke; C H Stuart-Harris
Journal:  J Infect Dis       Date:  1977-03       Impact factor: 5.226
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  3 in total

1.  Use of the enzyme-linked immunosorbent assay (ELISA) for the estimation of serum antibodies in an influenza virus vaccine study.

Authors:  R Jennings; T Smith; C W Potter
Journal:  Med Microbiol Immunol       Date:  1981       Impact factor: 3.402

2.  A comparison of adverse effects of two influenza vaccines, and the influence on subsequent uptake.

Authors:  M P Ryan; A F MacLeod
Journal:  J R Coll Gen Pract       Date:  1984-08

3.  Responses of volunteers to inactivated influenza virus vaccines.

Authors:  R Jennings; C W Potter; P M Massey; B I Duerden; J Martin; A M Bevan
Journal:  J Hyg (Lond)       Date:  1981-02
  3 in total

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