Literature DB >> 468729

Holomycin and an antibiotic (MM 19290) related to tunicamycin, metabolites of Streptomyces clavuligerus.

M Kenig, C Reading.   

Abstract

Streptomyces clavuligerus produces penicillin N, several cephalosporins and the beta-lactamase inhibitor clavulanic acid. The detection, isolation and properties of further metabolites of this culture, MM 21801 and MM 19290, are described. MM 21801 was identified as the antibiotic holomycin. MM 19290 was shown to be related to tunicamycin, an antibiotic complex obtained from cultures of Streptomyces lysosuperificus.

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Year:  1979        PMID： 468729     DOI： 10.7164/antibiotics.32.549

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  36 in total

1.  RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus.

Authors:  A O'Neill; B Oliva; C Storey; A Hoyle; C Fishwick; I Chopra
Journal:  Antimicrob Agents Chemother       Date:  2000-11       Impact factor: 5.191

2.  Computational-guided discovery and characterization of a sesquiterpene synthase from Streptomyces clavuligerus.

Authors:  Jeng-Yeong Chow; Bo-Xue Tian; Gurusankar Ramamoorthy; Brandan S Hillerich; Ronald D Seidel; Steven C Almo; Matthew P Jacobson; C Dale Poulter
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-21       Impact factor: 11.205

3.  Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus.

Authors:  Bo Li; Christopher T Walsh
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-01       Impact factor: 11.205

Review 4.  Oxidative Cyclization in Natural Product Biosynthesis.

Authors:  Man-Cheng Tang; Yi Zou; Kenji Watanabe; Christopher T Walsh; Yi Tang
Journal:  Chem Rev       Date:  2016-12-12       Impact factor: 60.622

5.  Antimicrobial properties and mode of action of the pyrrothine holomycin.

Authors:  B Oliva; A O'Neill; J M Wilson; P J O'Hanlon; I Chopra
Journal:  Antimicrob Agents Chemother       Date:  2001-02       Impact factor: 5.191

6.  Novel hybrid-type antimicrobial agents targeting the switch region of bacterial RNA polymerase.

Authors:  Fumika Yakushiji; Yuko Miyamoto; Yuki Kunoh; Reiko Okamoto; Hidemasa Nakaminami; Yuri Yamazaki; Norihisa Noguchi; Yoshio Hayashi
Journal:  ACS Med Chem Lett       Date:  2013-01-11       Impact factor: 4.345

7.  Induction of holomycin production and complex metabolic changes by the argR mutation in Streptomyces clavuligerus NP1.

Authors:  Hua Yin; Sihai Xiang; Jianting Zheng; Keqiang Fan; Tingting Yu; Xu Yang; Yanfeng Peng; Haibin Wang; Deqin Feng; Yuanming Luo; Hua Bai; Keqian Yang
Journal:  Appl Environ Microbiol       Date:  2012-02-17       Impact factor: 4.792

8.  The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.

Authors:  Marnix H Medema; Axel Trefzer; Andriy Kovalchuk; Marco van den Berg; Ulrike Müller; Wilbert Heijne; Liang Wu; Mohammad T Alam; Catherine M Ronning; William C Nierman; Roel A L Bovenberg; Rainer Breitling; Eriko Takano
Journal:  Genome Biol Evol       Date:  2010-07-12       Impact factor: 3.416

Review 9.  Scrutinizing the scaffolds of marine biosynthetics from different source organisms: Gram-negative cultured bacterial products enter center stage.

Authors:  Patrick C Still; Tyler A Johnson; Christine M Theodore; Steven T Loveridge; Phillip Crews
Journal:  J Nat Prod       Date:  2014-02-26       Impact factor: 4.050

Review 10.  The biosynthesis of nitrogen-, sulfur-, and high-carbon chain-containing sugars.

Authors:  Chia-I Lin; Reid M McCarty; Hung-wen Liu
Journal:  Chem Soc Rev       Date:  2013-01-25       Impact factor: 54.564
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