| Literature DB >> 4686179 |
A G Jabara, P H Toyne, A G Harcourt.
Abstract
A reduction in tumour yield was apparent when progesterone administration was begun 25 days before feeding 7,12-dimethylbenz(a)anthracene (DMBA). This effect was most obvious when the duration of hormone administration was brief. Continuation of progesterone for some time after feeding DMBA caused a progressive diminution of the inhibitory effect, and 135 days of continuous hormone treatment entirely abolished the effects of 25 days pretreatment with the hormone.In contrast, when progesterone injections were begun 2 days after feeding DMBA, there was a trend towards enhancement of tumour yield. Continuous hormone administration appeared more effective than shorter treatment regimens.Entities:
Keywords: Animals, Laboratory; Biology; Cancer; Clinical Research; Diseases; Endocrine System; Histology; Hormones; Incidence; Mammary Gland Effects; Measurement; Neoplasms; Physiology; Progestational Hormones; Progesterone--administraction and dosage; Research Methodology
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Year: 1973 PMID： 4686179 PMCID： PMC2008829 DOI： 10.1038/bjc.1973.8
Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640