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Literature DB >> 4685706

Consequent intrafamilial immunization for DL-A haplotyping in canines.

J A van der Does, J J van Rood, W S Walker, R B Epstein.

Abstract

A procedure of intrafamilial immunization is described for production of antisera recognizing DL-A haplotypes. In a colony consisting of 1 sire, 6 bitches, and 67 offspring all haplotypes could be accurately allocated. In the colony the observed reaction frequencies of the antisera are in agreement with mendelian codominant inheritance. Mixed lymphocyte culture tests confirmed the accuracy of the serologic typing and the presence of homozygous individuals within the colony. Further evidence is presented supporting the presence of two or more subloci within the DL-A system. Colonies of canines such as the one described should provide a sensitive system for evaluating interaction between serologic DL-A typing, MLC reactivity, and immune response genetics in a nonrodent species which is not highly inbred.

Entities: Species

Mesh：

Substances：
Immune Sera

Year: 1973 PMID： 4685706 PMCID： PMC2139492 DOI： 10.1084/jem.137.2.494

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

14 in total

1. Mixed-lymphocyte-culture and skin-graft data in unrelated HL-A identical individuals.

Authors: C T Koch; V P Eysvoogel; E Frederiks; J J van Rood
Journal: Lancet Date: 1971-12-18 Impact factor: 79.321

Review 2. Histocompatibility-linked immune response genes.

Authors: B Benacerraf; H O McDevitt
Journal: Science Date: 1972-01-21 Impact factor: 47.728

3. Determination of histocompatibility antigens by leukocyte typing in outbred guinea pigs and effect of matching on skin graft survival.

Authors: A L De Weck; L Polak; W Sato; J R Frey
Journal: Transplant Proc Date: 1971-03 Impact factor: 1.066

9. Histocompatibility studies in a closely bred colony of dogs. 3. Genetic definition of the DL-A system of canine histocompatibility, with particular reference to the comparative immunogenicity of the major transplantable organs.

Authors: J Dausset; F T Rapaport; F D Cannon; J W Ferrebee
Journal: J Exp Med Date: 1971-11-01 Impact factor: 14.307

10. Genetic control of the antibody response in inbred mice. Transfer of response by spleen cells and linkage to the major histocompatibility (H-2) locus.

Authors: H O McDevitt; M L Tyan
Journal: J Exp Med Date: 1968-07-01 Impact factor: 14.307

Consequent intrafamilial immunization for DL-A haplotyping in canines.

1. Mixed-lymphocyte-culture and skin-graft data in unrelated HL-A identical individuals.

Review 2. Histocompatibility-linked immune response genes.

3. Determination of histocompatibility antigens by leukocyte typing in outbred guinea pigs and effect of matching on skin graft survival.

4. Hu-1: Major histocompatibility locus in man.

5. Lymphocyte typing in allografted beagles.

6. Cytotoxic typing antisera for marrow grafting in littermate dogs.

7. New HL-A alleles. Identification by planned immunization.

8. Canine mixed leukocyte reactivity and transplantation antigens.

9. Histocompatibility studies in a closely bred colony of dogs. 3. Genetic definition of the DL-A system of canine histocompatibility, with particular reference to the comparative immunogenicity of the major transplantable organs.

10. Genetic control of the antibody response in inbred mice. Transfer of response by spleen cells and linkage to the major histocompatibility (H-2) locus.