| Literature DB >> 4685040 |
D G Marsh, W B Bias, S H Hsu, L Goodfriend.
Abstract
A relatively small proportion (17 percent) of individuals highly allergic to ragweed were found to develop marked reaginic (immunoglobulin E-mediated) skin sensitivity to a minor ragweed pollen allergen Ra5 (molecular weight 5200). Sensitivity to Ra5 was significantly associated with the possession of a major histocompatibility antigen of the HL-A7 cross-reacting group. This appears to be the first evidence of a strong association between a specific immune response and a specific group of closely related HL-A antigens in man.Entities:
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Year: 1973 PMID: 4685040 DOI: 10.1126/science.179.4074.691
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728