Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Delta-9-tetrahydrocannabinol: localization in body fat.

Literature DB >> 4682965

Delta-9-tetrahydrocannabinol: localization in body fat.

Abstract

[(14)C]Delta(9)-Tetrahydrocannabinol (Delta(9)THC) was injected subcutaneously in rats every day for 1 to 26 days. Concentrations of Delta(9)THC and its metabolites, 11-hydroxytetrahydrocannabinol and 8,11-dihydroxytetrahydrocannabinol, were determined in various tissues. After a single injection, the concentration of Delta(9)THC in fat was ten times greater than in any other tissue examined, and persisted in this tissue for 2 weeks. With repeated injection, Delta(9)THC and its metabolites accumulated in fat and brain.

Entities: Chemical Species

Mesh：

Substances：

Year: 1973 PMID： 4682965 DOI： 10.1126/science.179.4071.391

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

Keyword Cloud
Cited

36 in total

1. Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors.

Authors: Amy K Dickason-Chesterfield; Stephanie R Kidd; Steven A Moore; John M Schaus; Bin Liu; George G Nomikos; Christian C Felder
Journal: Cell Mol Neurobiol Date: 2006-05-31 Impact factor: 5.046

Review 2. Human cannabinoid pharmacokinetics.

Authors: Marilyn A Huestis
Journal: Chem Biodivers Date: 2007-08 Impact factor: 2.408

3. Δ(9)-Tetrahydrocannabinol treatment during human monocyte differentiation reduces macrophage susceptibility to HIV-1 infection.

Authors: Julie C Williams; Sofia Appelberg; Bruce A Goldberger; Thomas W Klein; John W Sleasman; Maureen M Goodenow
Journal: J Neuroimmune Pharmacol Date: 2014-02-23 Impact factor: 4.147

4. Urinary 11-nor-9-carboxy-tetrahydrocannabinol elimination in adolescent and young adult cannabis users during one month of sustained and biochemically-verified abstinence.

Authors: Randi Melissa Schuster; Kevin Potter; Ryan Vandrey; Maya Hareli; Jodi Gilman; David Schoenfeld; A Eden Evins
Journal: J Psychopharmacol Date: 2019-09-19 Impact factor: 4.153

5. The first report of the National Commission on marihuana (1972): signal of misunderstanding or exercise in ambiguity.

Authors: G G Nahas; A Greenwood
Journal: Bull N Y Acad Med Date: 1974-01

6. Proceedings of the Fiftieth Anniversary Meeting of the British Pharmacological Society, University of Oxford, 16-18 September 1981. Abstracts.

Authors:
Journal: Br J Pharmacol Date: 1981-12 Impact factor: 8.739

7. The Differential Binding of Antipsychotic Drugs to the ABC Transporter P-Glycoprotein Predicts Cannabinoid-Antipsychotic Drug Interactions.

Authors: Natalia I Brzozowska; Erik J de Tonnerre; Kong M Li; Xiao Suo Wang; Aurelie A Boucher; Paul D Callaghan; Michael Kuligowski; Alex Wong; Jonathon C Arnold
Journal: Neuropsychopharmacology Date: 2017-03-08 Impact factor: 7.853