Literature DB >> 4682251

Mechanism of action of vitamin K: demonstration of a liver precursor of prothrombin.

J W Suttie.   

Abstract

Extracts of sonicated liver microsomes that are prepared from rats deficient in vitamin K or from rats given vitamin K antagonists contain a factor that liberates a thrombin-like activity when it is incubated with venom from Echis carinatus. The amount of this factor is low in control rats and in hypoprothrombinemic rats given vitamin K 1 hour before they were killed. These data indicate that this factor is a protein precursor of prothrombin, which is synthesized in the liver.

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Year:  1973        PMID： 4682251     DOI： 10.1126/science.179.4069.192

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  11 in total

1.  Control of anticoagulation in rats.

Authors:  A T Van Oosterom; J J Veltkamp
Journal:  Experientia       Date:  1974-08-15

2.  Oral anticoagulants--the totem and the taboo.

Authors:  A Breckenridge
Journal:  Br Med J       Date:  1976-02-21

Review 3.  Post-translational carboxylation of preprothrombin.

Authors:  B C Johnson
Journal:  Mol Cell Biochem       Date:  1981-08-11       Impact factor: 3.396

4.  The apparent absence of involvement of biotin in the vitamin K-dependent carboxylation of glutamic acid residues of proteins.

Authors:  P A Friedman; M A Shia
Journal:  Biochem J       Date:  1977-04-01       Impact factor: 3.857

5.  Bothrops jararaca envenomation: Pathogenesis of hemostatic disturbances and intravascular hemolysis.

Authors:  Luana V Senise; Karine M Yamashita; Marcelo L Santoro
Journal:  Exp Biol Med (Maywood)       Date:  2015-06-16

6.  The mode of action of vitamin K. Isolation of a peptide containing the vitamin K-dependent portion of prothrombin.

Authors:  G L Nelsestuen; J W Suttie
Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205

7.  Changes in phylloquinone epoxidase activity related to prothrombin synthesis and microsomal clotting activity in the rat.

Authors:  A K Willingham; J T Matschiner
Journal:  Biochem J       Date:  1974-06       Impact factor: 3.857

8.  [Preprothrombin in acute viral hepatitis B].

Authors:  H U Lautz; M Barthels; E Schmidt; F W Schmidt
Journal:  Klin Wochenschr       Date:  1982-11-15

9.  Characterization of vitamin K-dependent carboxylase from the livers from the adult ox and dicoumarol-treated calf.

Authors:  L Uotila; J W Suttie
Journal:  Biochem J       Date:  1982-02-01       Impact factor: 3.857

10.  Vitamin K-dependent synthesis and modification of precursor prothrombin in cultured H-35 hepatoma cells.

Authors:  T W Munns; M F Johnston; M K Liszewski; R E Olson
Journal:  Proc Natl Acad Sci U S A       Date:  1976-08       Impact factor: 11.205
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