Literature DB >> 4680803

Two new antimetabolites of biotin: alpha-methyldethiobiotin and alpha-methylbiotin.

L J Hanka, D G Martin, L M Reineke.   

Abstract

Two new antimetabolites of biotin were isolated from culture filtrates of Streptomyces lydicus: beta-methyldethiobiotin and beta-methylbiotin. (14)C-biotin or (14)C-pimelic acid was not incorporated into either of these antimetabolites by the growing culture. Neither of the compounds could substitute for the biotin requirement in Saccharomyces cerevisiae. Both compounds had a strong and rather specific antimicrobial effect against mycobacteria. Their antimicrobial activities were reversed by biotin. Both compounds had an affinity for avidin.

Entities:  

Mesh：

Substances：

Year:  1972        PMID： 4680803      PMCID： PMC444181          DOI： 10.1128/AAC.1.2.135

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  5 in total

1.  HEAT STABILITY OF AVIDIN AND AVIDIN-BIOTIN COMPLEX AND INFLUENCE OF IONIC STRENGTH ON AFFINITY OF AVIDIN FOR BIOTIN.

Authors:  R D WEI; L D WRIGHT
Journal:  Proc Soc Exp Biol Med       Date:  1964-11

2.  Bacterial degradation of biotin. Catabolism of 14C-biotin and its sulfoxides.

Authors:  R N Brady; H Ruis; D B McCormick; L D Wright
Journal:  J Biol Chem       Date:  1966-10-25       Impact factor: 5.157

3.  Naturally occurring antimetabolite antibiotic related to biotin.

Authors:  L J Hanka; M E Bergy; R B Kelly
Journal:  Science       Date:  1966-12-30       Impact factor: 47.728

4.  The biosynthesis of biotin in growing yeast cells: The formation of biotin from an early intermediate.

Authors:  M A Eisenberg
Journal:  Biochem J       Date:  1966-12       Impact factor: 3.857

5.  Biological studies with alpha-dehydrobiotin.

Authors:  L J Hanka; L M Reineke; D G Martin
Journal:  J Bacteriol       Date:  1969-10       Impact factor: 3.490
  5 in total
  6 in total

1.  Construction of a Biotin-Overproducing Strain of Serratia marcescens.

Authors:  N Sakurai; Y Imai; M Masuda; S Komatsubara; T Tosa
Journal:  Appl Environ Microbiol       Date:  1993-09       Impact factor: 4.792

2.  U-42, 126, a new antimetabolite antibiotic: production, biological activity, and taxonomy of the producing microorganism.

Authors:  L J Hanka; A Dietz
Journal:  Antimicrob Agents Chemother       Date:  1973-03       Impact factor: 5.191

3.  Mode of action of alpha-dehydrobiotin, a biotin analogue.

Authors:  M A Eisenberg
Journal:  J Bacteriol       Date:  1975-07       Impact factor: 3.490

4.  Mode of action of the biotin antimetabolites actithiazic acid and alpha-methyldethiobiotin.

Authors:  M A Eisenberg; S C Hsiung
Journal:  Antimicrob Agents Chemother       Date:  1982-01       Impact factor: 5.191

5.  Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens.

Authors:  Lindsey A Carfrae; Craig R MacNair; Christopher M Brown; Caressa N Tsai; Brent S Weber; Soumaya Zlitni; Vishwas N Rao; Joshua Chun; Murray S Junop; Brian K Coombes; Eric D Brown
Journal:  Nat Microbiol       Date:  2019-10-28       Impact factor: 30.964

6.  Active and inactive forms of biotin synthase occur in Heterodera glycines.

Authors:  Khee Man Kwon; Sadia Bekal; Leslie L Domier; Kris N Lambert
Journal:  J Nematol       Date:  2019-10-25       Impact factor: 1.402
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.