Literature DB >> 467608

Studies on the activity of phorbol myrystate acetate on the human polymorphonuclear leukocytes.

Z Spirer, V Zakuth, S Diamant, Y Stabinsky, M Fridkin.   

Abstract

Phorbol myrystate acetate (PMA) activates nitroblue tetrazolium reduction in human polymorphs. The activation is inhibited by dibutyryl cyclic AMP, theophylline and phenylbutazone, but is not influenced by hydrocortisone in vitro, nor is it inhibited by leukocytes from patients treated with prednisone. Peptide analogues of Tuftsin also had no effect on this stimulatory activity. We conclude that the action of PMA on the nitroblue tetrazolium reduction is mediated through cyclic nucleotides.

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Year:  1979        PMID： 467608     DOI： 10.1007/bf01968279

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  The influence of cyclic nucleotides (c-AMP and c-GMP) on the nitrous blue tetrazolium reduction by human polymorphonuclear leucocytes.

Authors:  Z Spirer; V Zakuth; A Golander; N Bogair
Journal:  Experientia       Date:  1975-01-15

2.  The influence of phorbol myristate acetate on the metabolism of neutrophils from carriers of sex-linked chronic granulomatous disease.

Authors:  J E Repine; J G White; C C Clawson; B H Holmes
Journal:  J Lab Clin Med       Date:  1975-01

3.  The influence of phorbol myristate acetate on oxygen consumption by polymorphonuclear leukocytes.

Authors:  J E Repine; J G White; C C Clawson; B M Holmes
Journal:  J Lab Clin Med       Date:  1974-06

4.  Quantitative nitroblue tetrazolium test in chronic granulomatous disease.

Authors:  R L Baehner; D G Nathan
Journal:  N Engl J Med       Date:  1968-05-02       Impact factor: 91.245

5.  The effect of corticosteroids on the bactericidal activity of leucocytes.

Authors:  Z Spirer; V Zakuth; Y Weisman; N Bogair
Journal:  Experientia       Date:  1974-03-15

6.  Effect of phenylbutazone on phagocytosis and intracellular killing by guinea pig polymorphonuclear leukocytes.

Authors:  R R Strauss; B B Paul; A J Sbarra
Journal:  J Bacteriol       Date:  1968-12       Impact factor: 3.490

7.  Effect of phorbol myristate acetate on the oxidative metabolism of human polymorphonuclear leukocytes.

Authors:  L R DeChatelet; P S Shirley; R B Johnston
Journal:  Blood       Date:  1976-04       Impact factor: 22.113

8.  The effect of Tuftsin on the nitrous blue tetrazolium reduction of normal human polymorphonuclear leukocytes.

Authors:  Z Spirer; V Zakuth; A Golander; N Bogair; M Fridkin
Journal:  J Clin Invest       Date:  1975-01       Impact factor: 14.808

9.  The effect of an NADH oxidase inhibitor (hydrocortisone) on polymorphonuclear leukocyte bactericidal activity.

Authors:  G L Mandell; W Rubin; E W Hook
Journal:  J Clin Invest       Date:  1970-07       Impact factor: 14.808

10.  Effects of phorbol myristate acetate on the metabolism and ultrastructure of neutrophils in chronic granulomatous disease.

Authors:  J E Repine; J G White; C C Clawson; B M Holmes
Journal:  J Clin Invest       Date:  1974-07       Impact factor: 14.808
  10 in total
  1 in total

1.  [Effect of phorbolmyristate acetate and bacterial lipopolysaccharides on the luminal chemiluminescence of neutrophil granulocytes].

Authors:  C Eschenbach
Journal:  Klin Wochenschr       Date:  1983-05-02
  1 in total

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