Literature DB >> 467601

Choleretic and cholestatic effects of infused bile salts in the rat.

R Drew, B G Priestly.   

Abstract

In rats, at low infusion rates taurocholate (TC), taurochenodeoxycholate (TCDC) and taurodeoxycholate (TCD) each produced an increase in bile flow of 20-50%. However, at high infusion rates (5-20 mumoles min-1kg-1) the cholestatic effects of the bile salts were revealed and the relative toxicity of the bile salts was seen to be TDC greater than TCDC greater than TC.

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Year:  1979        PMID： 467601     DOI： 10.1007/bf01968265

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  17 in total

Review 1.  Mechanisms and control of secretion of bile water and electrolytes.

Authors:  S Erlinger; D Dhumeaux
Journal:  Gastroenterology       Date:  1974-02       Impact factor: 22.682

2.  Taurocholate excertion and bile formation in the isolated perfused rat liver. An in vitro-in vivo comparison.

Authors:  G Paumgartner; R Herz; K Sauter; H P Schwarz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

3.  Cholestasis is the result of hypoactive hypertrophic smooth endoplasmic reticulum in the hepatocyte.

Authors:  F Schaffner; H Popper
Journal:  Lancet       Date:  1969-08-16       Impact factor: 79.321

4.  Comparison of the choleretic properties of bile acids.

Authors:  C D Klaassen
Journal:  Eur J Pharmacol       Date:  1973-09       Impact factor: 4.432

5.  Biochemical and morphological parameters of taurolithocholate-induced cholestasis.

Authors:  B G Priestly; M G Côté; G L Plaa
Journal:  Can J Physiol Pharmacol       Date:  1971-12       Impact factor: 2.273

6.  Kinetics of taurocholate uptake by the perfused rat liver.

Authors:  J Reichen; G Paumgartner
Journal:  Gastroenterology       Date:  1975-01       Impact factor: 22.682

Review 7.  Pathophysiology of cholestasis.

Authors:  H Popper; F Schaffner
Journal:  Hum Pathol       Date:  1970-03       Impact factor: 3.466

8.  Uptake of bile acids by perfused rat liver.

Authors:  J Reichen; G Paumgartner
Journal:  Am J Physiol       Date:  1976-09

9.  Inhibition of bile formation by high doses of taurocholate in the perfused rat liver.

Authors:  R Herz; G Paumgartner; R Preisig
Journal:  Scand J Gastroenterol       Date:  1976       Impact factor: 2.423

10.  Serum bile acids in liver disease.

Authors:  G Neale; B Lewis; V Weaver; D Panveliwalla
Journal:  Gut       Date:  1971-02       Impact factor: 23.059
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  9 in total

1.  Acute effects of cholestatic and choleretic bile salts on vasopressin- and glucagon-induced hepato-biliary calcium fluxes in the perfused rat liver.

Authors:  Y Hamada; A Karjalainen; B A Setchell; J E Millard; F L Bygrave
Journal:  Biochem J       Date:  1992-04-15       Impact factor: 3.857

Review 2.  Cellular mechanisms of intrahepatic cholestasis.

Authors:  P J Meier-Abt
Journal:  Drugs       Date:  1990       Impact factor: 9.546

3.  Biliary bile acids in primary biliary cirrhosis: effect of ursodeoxycholic acid.

Authors:  B Combes; R L Carithers; W C Maddrey; S Munoz; G Garcia-Tsao; G F Bonner; J L Boyer; V A Luketic; M L Shiffman; M G Peters; H White; R K Zetterman; R Risser; S S Rossi; A F Hofmann
Journal:  Hepatology       Date:  1999-06       Impact factor: 17.425

4.  Properties of the canalicular bile acid transport system in rat liver.

Authors:  P J Meier; A S Meier-Abt; J L Boyer
Journal:  Biochem J       Date:  1987-03-01       Impact factor: 3.857

5.  Lithocholate glucuronide is a cholestatic agent.

Authors:  D G Oelberg; M V Chari; J M Little; E W Adcock; R Lester
Journal:  J Clin Invest       Date:  1984-06       Impact factor: 14.808

6.  Synthesis and metabolism of sodium 3 alpha,7 alpha-dihydroxy-25,26-bishomo-5 beta-cholane-26-sulfonate in the hamster.

Authors:  T Mikami; E H Mosbach; B I Cohen; N Ayyad; M Yoshii; K Kihira; T Hoshita
Journal:  Lipids       Date:  1995-01       Impact factor: 1.880

7.  Comparative studies on bile flow and biliary lipid excretion after bile-acid loading in normal and partially hepatectomized rats.

Authors:  M Hoshino; A Hirano; T Hayakawa; Y Kamiya; T Ohiwa; A Tanaka; T Kumai; K Katagiri; M Miyaji; T Takeuchi
Journal:  Biochem J       Date:  1995-01-15       Impact factor: 3.857

8.  Bile acid glycine and taurine conjugates in serum of patients with primary biliary cirrhosis: effect of ursodeoxycholic treatment.

Authors:  Y Chretien; R Poupon; M F Gherardt; O Chazouilleres; D Labbe; A Myara; F Trivin
Journal:  Gut       Date:  1989-08       Impact factor: 23.059

9.  ABC gene-ranking for prediction of drug-induced cholestasis in rats.

Authors:  Yauheniya Cherkas; Michael K McMillian; Dhammika Amaratunga; Nandini Raghavan; Jennifer C Sasaki
Journal:  Toxicol Rep       Date:  2016-01-18
  9 in total

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