Literature DB >> 467596

Percutaneous penetration of indomethacin.

H Ishihama, H Kimata, Y Mizushima.   

Abstract

14C-Indomethacin (ID) was applied to the skin of guinea-pigs as an ointment. After several applications, the concentration of ID in the skin and muscle under the applied site reached a constant level. The concentration of ID in the muscle as well as the skin may be enough to exert an anti-inflammatory effect.

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Year:  1979        PMID： 467596     DOI： 10.1007/bf01968257

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  2 in total

1.  Simultaneous pharmacokinetics of indomethacin in serum and synovial fluid.

Authors:  H W Emori; G D Champion; R Bluestone; H E Paulus
Journal:  Ann Rheum Dis       Date:  1973-09       Impact factor: 19.103

2.  Physiologic disposition and metabolic fate of indomethacin analogs. I. 1-p-chlorobenzylidenyl-5-methoxy-2-methylindene-3-acetic acid.

Authors:  H B Hucker; E A Hoffman
Journal:  J Pharm Sci       Date:  1971-07       Impact factor: 3.534
  2 in total
  2 in total

1.  A physiological pharmacokinetic model for solute disposition in tissues below a topical below a topical application site.

Authors:  M S Roberts; S E Cross
Journal:  Pharm Res       Date:  1999-09       Impact factor: 4.200

Review 2.  Topical NSAIDs for musculoskeletal conditions. A review of the literature.

Authors:  J H Vaile; P Davis
Journal:  Drugs       Date:  1998-11       Impact factor: 9.546
  2 in total

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