Literature DB >> 467468

Comparative distribution of two antidepressant drugs (imipramine and indalpine) in the rat as determined by analog computer simulation.

G Le Fur, J Amouroux, F Roquet, A Uzan.   

Abstract

A ten-compartment analog computer model is presented to determine the precise distribution and excretion of two antidepressant drugs, LM 5008 AND Imipramine. Eight patterns were simulated using experimental data and drug distribution in the two undetermined compartments were obtained by the analog model. Close agreement with existing experimental data lends confidence in the model as a valuable tool for predictions in a variety of therapeutic situations.

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Year:  1979        PMID： 467468     DOI： 10.1007/BF03189393

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  5 in total

1.  THE DISTRIBUTION AND FATE OF D-TUBOCURARINE.

Authors:  E N COHEN; A CORBASCIO; G FLEISCHLI
Journal:  J Pharmacol Exp Ther       Date:  1965-01       Impact factor: 4.030

2.  On the regional and specific serotonin uptake inhibition by LM 5008.

Authors:  G Le Fur; M Kabouche; A Uzan
Journal:  Life Sci       Date:  1978-11-09       Impact factor: 5.037

3.  Effects of 4-(3-indolyl-alkyl) piperidine derivatives on brain 5-hydroxytryptamine turnover and on cardiac and brain noradrenaline or 5-hydroxytryptamine depletion induced by 6-hydroxydopamine, H 75/12 and 4-chloroamphetamine.

Authors:  G Le Fur; N Mitrani; A Uzan
Journal:  Biochem Pharmacol       Date:  1977-03-15       Impact factor: 5.858

4.  Effects of 4-(3-indolyl-alkyl)piperidine derivatives on uptake and release of noradrenaline, dopamine and 5-hydroxytryptamine in rat brain synaptosomes, rat heart and human blood platelets.

Authors:  G Le Fur; A Uzan
Journal:  Biochem Pharmacol       Date:  1977-03-15       Impact factor: 5.858

5.  [Absorption, distribution and excretion of (quinuclidinyl-3 methyl)-10-phenothiazine (LM 209), a new antihistamine].

Authors:  A Uzan; C Gueremy; G Le Fur
Journal:  Xenobiotica       Date:  1976-10       Impact factor: 1.908
  5 in total

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