Literature DB >> 4673487

Virus-specific ribonucleic acid in the nucleus and cytoplasm of rat embryo cells transformed by adenovirus type 2.

K Shimada, K Fujinaga, S Hama, K Sekikawa, Y Ito.   

Abstract

Nuclei were isolated from rat embryo cells transformed by adenovirus type 2. Nuclear and cytoplasmic virus-specific ribonucleic acids (RNA) were characterized and quantitated by deoxyribonucleic acid (DNA)-RNA hybrid formation with adenovirus DNA. The results indicate that most, if not all, virus-specific RNA molecules are synthesized in the cell nucleus and subsequently transported into cytoplasm where they degrade with a half-life of 1 to 2 hr. No difference in base sequences between nuclear and cytoplasmic virus-specific RNA species can be detected by hybridization competition experiment with viral DNA.

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Year:  1972        PMID： 4673487      PMCID： PMC356515     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  17 in total

1.  Biochemical studies on adenovirus multiplication. IV. Isolation, purification, and chemical analysis of adenovirus.

Authors:  M GREEN; M PINA
Journal:  Virology       Date:  1963-05       Impact factor: 3.616

2.  SV40-specific RNA in the nucleus and polyribosomes of transformed cells.

Authors:  U Lindberg; J E Darnell
Journal:  Proc Natl Acad Sci U S A       Date:  1970-04       Impact factor: 11.205

3.  Transformation of primary rat embryo cells by adenovirus type 2.

Authors:  A E Freeman; P H Black; E A Vanderpool; P H Henry; J B Austin; R J Huebner
Journal:  Proc Natl Acad Sci U S A       Date:  1967-09       Impact factor: 11.205

4.  Competition hybridization by "pre-saturation" of HeLa cell DNA.

Authors:  R Soeiro; J E Darnell
Journal:  J Mol Biol       Date:  1969-09-28       Impact factor: 5.469

5.  The mechanism of viral carcinogenesis by DNA mammalian viruses: viral-specific RNA in polyribosomes of adenovirus tumor and transformed cells.

Authors:  K Fujinaga; M Green
Journal:  Proc Natl Acad Sci U S A       Date:  1966-06       Impact factor: 11.205

6.  Rapidly labeled HeLa cell nuclear RNA. I. Identification by zone sedimentation of a heterogeneous fraction separate from ribosomal precursor RNA.

Authors:  J R Warner; R Soeiro; H C Birnboim; M Girard; J E Darnell
Journal:  J Mol Biol       Date:  1966-08       Impact factor: 5.469

7.  RNA metabolism in the HeLa cell nucleus.

Authors:  S Penman
Journal:  J Mol Biol       Date:  1966-05       Impact factor: 5.469

8.  Mechanism of viral carcinogenesis by DNA Mammalian viruses, ii. Viral-specific RNA in tumor cells induced by "weakly" oncogenic human adenoviruses.

Authors:  K Fujinaga; M Green
Journal:  Proc Natl Acad Sci U S A       Date:  1967-03       Impact factor: 11.205

9.  The mechanism of viral carcinogenesis by DNA mammalian viruses: RNA transcripts containing viral and highly reiterated cellular base sequences in adenovirus-transformed cells (DNA-RNA hybridization-viral-cell mRNA).

Authors:  D Tsuei; K Fujinaga; M Green
Journal:  Proc Natl Acad Sci U S A       Date:  1972-02       Impact factor: 11.205

10.  Mechanism of viral carcinogenesis by DNA mammalian viruses. VII. Viral genes transcribed in adenovirus type 2 infected and transformed cells.

Authors:  K Fujinaga; M Green
Journal:  Proc Natl Acad Sci U S A       Date:  1970-02       Impact factor: 11.205
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  3 in total

1.  Herpesvirus infection modifies adenovirus RNA metabolism in adenovirus type 5-transformed cells.

Authors:  D Spector; L I Pizer
Journal:  J Virol       Date:  1978-07       Impact factor: 5.103

2.  Role of the nuclear matrix in the growth of herpes simplex virus type 2.

Authors:  Y Tsutsui; Y Nishiyama; S Yoshida; K Maeno; M Hoshino
Journal:  Arch Virol       Date:  1983       Impact factor: 2.574

3.  Two "early" mRNA species in adenovirus type 2-transformed rat cells.

Authors:  S J Flint
Journal:  J Virol       Date:  1977-07       Impact factor: 5.103
  3 in total

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