Literature DB >> 4673045

Obesity: evidence of decreased secretion of glucagon.

J K Wise, R Hendler, P Felig.   

Abstract

The increase in concentration of glucagon in plasma caused by infusion of alanine was reduced in obese subjects as compared to that in nonobese control subjects. This was true when the subjects were in the postabsorptive state as well as after an 84-hour fast, at which time the basal glucagon concentration had risen in the nonobese subjects, but remained unaltered in the obese group.

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Year:  1972        PMID: 4673045     DOI: 10.1126/science.178.4060.513

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  5 in total

1.  Hypoketonaemic effect of L-alamine. Specific decrease in blood concentrations of 3-hydroxybutyrate in the rat.

Authors:  P T Ozand; W D Reed; J Girard; R L Hawkins; R M Collins; J T Tildon; M Cornblath
Journal:  Biochem J       Date:  1977-06-15       Impact factor: 3.857

2.  Childhood obesity and carbohydrate intolerance.

Authors: 
Journal:  Br Med J       Date:  1973-07-21

3.  Influence of glucocorticoids on glucagon secretion and plasma amino acid concentrations in man.

Authors:  J K Wise; R Hendler; P Felig
Journal:  J Clin Invest       Date:  1973-11       Impact factor: 14.808

4.  Plasma concentrations of glucagon during hyperglycemic clamp with or without somatostatin infusion in obese subjects.

Authors:  E Bonora; P Moghetti; V Cacciatori; M Zenere; F Tosi; D Travia; G Zoppini; L Perobelli; M Muggeo
Journal:  Acta Diabetol Lat       Date:  1990 Oct-Dec

5.  Pancreatic alpha-cells from female mice undergo morphofunctional changes during compensatory adaptations of the endocrine pancreas to diet-induced obesity.

Authors:  Beatriz Merino; Paloma Alonso-Magdalena; Mónica Lluesma; Patricia Ñeco; Alejandro Gonzalez; Laura Marroquí; Marta García-Arévalo; Angel Nadal; Ivan Quesada
Journal:  Sci Rep       Date:  2015-06-25       Impact factor: 4.379

  5 in total

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