Literature DB >> 4672239

6-Hydroxydopa depletion of brain norepinephrine and the function of aggressive behavior.

N B Thoa, B Eichelman, J S Richardson, D Jacobowitz.   

Abstract

A significant increase in shock-induced aggression occurs in the rat 4 days after an intraventricular injection of 90 micrograms of 6-hydroxydopa. Both fluorescent histology and biochemical assay demonstrate that brain norepinephrine is reduced by 90 micrograms of 6-hydroxydopa, while brain dopamine remains unaltered. This suggests that one form of aggressive behavior (shock-induced aggression) is modulated through a central noradrenergic system.

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Year:  1972        PMID: 4672239     DOI: 10.1126/science.178.4056.75

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  6 in total

1.  Professional biographical sketch.

Authors:  David M Jacobowitz
Journal:  Neurotox Res       Date:  2004       Impact factor: 3.911

2.  Dibutyryl cyclic AMP and adrenaline increase contractile force and 45 Ca uptake in mammalian cardiac muscle.

Authors:  T Meinertz; H Nawrath; H Scholz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

3.  Effects on shock-elicited aggression in mice of preferentially protecting brain monoamines against the depleting action of reserpine.

Authors:  L L Butcher; A P Dietrich
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

4.  Behavioural and biochemical effects of 6-hydroxydopa in rats.

Authors:  K Kmieciak-Kolada; Z S Herman; J Slomińska-Zurek
Journal:  Psychopharmacologia       Date:  1974-03-09

5.  Facilitation of shock-induced fighting following intraventricular 5,7-dihydroxytryptamine and 6-hydroxydopa.

Authors:  K M Kantak; L R Hegstrand; B Eichelman
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

Review 6.  Epilepsy, Antiepileptic Drugs, and Aggression: An Evidence-Based Review.

Authors:  Martin J Brodie; Frank Besag; Alan B Ettinger; Marco Mula; Gabriella Gobbi; Stefano Comai; Albert P Aldenkamp; Bernhard J Steinhoff
Journal:  Pharmacol Rev       Date:  2016-07       Impact factor: 25.468

  6 in total

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